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Upstream product

• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 107-30-2 chloromethyl methyl ether 
• 106-44-5 p-cresol 
• 25458-49-5 1-(methoxymethoxy)-4-methylbenzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 115560-39-9 3-Hydroxy-3-(2-methoxymethoxy-5-methyl-phenyl)-N,N-dimethyl-propionamide 
• 92-48-8 6-methylcoumarin 
• 1435268-11-3 (5,6-dimethoxy-2,2-dimethyl-2H-benzopyran-7-yl)(2-(methoxymethoxy)-5-methylphenyl)methanol 
• 1435268-30-6 (5,6-dimethoxy-2,2-dimethyl-2H-benzopyran-8-yl)(2-(methoxymethoxy)-5-methylphenyl)methanol 
• 1435268-46-4 (5,6-dimethoxy-2,2-dimethyl-2H-benzopyran-7-yl)(2-(methoxymethoxy)-5-methylphenyl)methanone 
• 1435268-61-3 (5,6-dimethoxy-2,2-dimethyl-2H-benzopyran-8-yl)(2-(methoxymethoxy)-5-methylphenyl)methanone 
• 1435268-77-1 (5,6-dimethoxy-2,2-dimethyl-2H-benzopyran-7-yl)(2-hydroxy-5-methylphenyl)methanone 
• 1435268-96-4 (5,6-dimethoxy-2,2-dimethyl-2H-benzopyran-8-yl)(2-hydroxy-5-methylphenyl)methanone 
• 124936-74-9 N,N-diiso-propyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine 
• 40546-94-9 6-methyl-4-phenyl-3,4-dihydrocoumarin 
• 16299-22-2 6-methyl-4-phenylchromen-2-one 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 

Relevant academic research and scientific papers

Metal-free annulative hydrosulfonation of propiolate esters: synthesis of 4-sulfonates of coumarins and butenolides

An efficient metal-free and cost-effective method for the synthesis of coumarin and butenolide 4-sulfonates (46 examples) has been developed. The reaction involves addition of sulfonic acids to ethyl propiolates followed by lactonization, resulting in direct formation of coumarin and butenolide 4-sulfonates. This methodology has been elaborated to Sonogashira and Suzuki coupling including the synthesis of rac-tolterodine.

Ni-Catalyzed Cycloisomerization between 3-Phenoxy Acrylic Acid Derivatives and Alkynes via Intramolecular Cleavage and Formation of the C-O Bond to Give 2,3-Disubstituted Benzofurans

Reactions based on transition-metal-catalyzed C-O bond cleavage have attracted much attention as a new synthetic method. Until now, several intermolecular reactions via C-O bond cleavage of aryl ethers, alkenyl ethers, esters, and others have been reported. Here we report an unprecedented C-O bond cleavage of 3-phenoxy acrylic acid derivatives, followed by intramolecular C-O bond formation with alkynes. This reaction gave 2,3-disubstituted benzofurans having useful functional groups-silyl substituents and acrylic acid derivatives- A t the 2- A nd 3-positions, respectively. This report also described theoretical (DFT) insights into the mechanism.

Multidimensional optimization of promising antitumor xanthone derivatives

A promising antitumor xanthone derivative was optimized following a multidimensional approach that involved the synthesis of 17 analogues, the study of their lipophilicity and solubility, and the evaluation of their growth inhibitory activity on four human tumor cell lines. A new synthetic route for the hit xanthone derivative was also developed and applied for the synthesis of its analogues. Among the used cell lines, the HL-60 showed to be in general more sensitive to the compounds tested, with the most potent compound having a GI50 of 5.1 μM, lower than the hit compound. Lipophilicity was evaluated by the partition coefficient (Kp) of a solute between buffer and two membrane models, namely liposomes and micelles. The compounds showed a log Kp between 3 and 5 and the two membrane models showed a good correlation (r2 = 0.916) between each other. Studies concerning relationship between solubility and structure were developed for the hit compound and 5 of its analogues.

CONJUGATED AROMATIC COMPOUND, OPTICAL MATERIAL, AND OPTICAL ELEMENT

The present invention relates to a conjugated aromatic compound represented by the Formula (1) in claim 1 (in the formula, Ar1 represents a hydrogen atom or an aryl group optionally having a substituent; Ar2 and Ar3 each represent a hydrogen atom or an aryl group optionally having a substituent but at least one of Ar2 and Ar3 represents an aryl group optionally having a substituent; and A represents an aromatic hydrocarbon group) and relates to an optical material containing the conjugated aromatic compound. The conjugated aromatic compound and the optical material have characteristics of a high chromatic aberration correction function, high refractive-index dispersion characteristics (Abbe number (vd)) and high secondary dispersion characteristics (θg,F) (anomalous dispersion characteristics).

HETEROAROMATIC-CONTAINING COMPOUND, OPTICAL MATERIAL AND OPTICAL ELEMENT

There are provided a heteroaromatic-containing compound represented by the following general formula (1), and an optical material including the heteroaromatic-containing compound. Formula 1 General Formula (1) wherein R1 and R2 are each independently a hydrogen atom or a methyl group, Ar1 is an aryl group which may have a substituent, and A is an aromatic hydrocarbon group. The R1 and R2 can be a hydrogen atom, and Ar1 can be a phenyl group.

Rhodium/chiral diene-catalyzed asymmetric 1,4-addition of arylboronic acids to arylmethylene cyanoacetates

Asymmetric 1,4-addition of arylboronic acids to (￡)-methyl 2-cyano-3-arylpropenoates proceeded in the presence of a rhodium catalyst (3 mol %) coordinated with a chiral diene ligand, (R,R)-Ph-bod*, to give high yields of the corresponding methyl 3,3-diaryl-2-cyanopropanoates with high enantioselectivity (up to 99% ee). This catalytic asymmetric transformation was applied to the asymmetric synthesis of (R)-tolterodine. American Chemical Society.