5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)ethyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

Base Information

Chemical Name:5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)ethyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide
CAS No.:1378427-87-2
Molecular Formula:C₂₉H₂₈BFN₂O₆S
Molecular Weight:562.427
Hs Code.:

5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)ethyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

Synonyms:5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)ethyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

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Chemical Property of 5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)ethyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

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Technology Process of 5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)ethyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

There total 18 articles about 5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)ethyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1378431-26-5
methyl 5-(1-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)ethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 1378427-87-2
5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)ethyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

Guidance literature:: methyl 5-(1-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)ethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

With water; In tetrahydrofuran; Cooling with ice;

Reference yield:

: 717880-58-5
2-bromo-5-iodobenzoic acid methyl ester

: 1378427-87-2
5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)ethyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 120 °C

2.1: hydrogen bromide / water / 2 h / 90 °C

3.1: potassium carbonate / acetonitrile / 24 h / 80 °C

4.1: potassium carbonate / acetonitrile / 3 h / 80 °C

5.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 100 °C / Inert atmosphere

6.1: lithium borohydride / tetrahydrofuran / 2 h / 0 - 20 °C

6.2: Cooling with ice

With lithium borohydride; hydrogen bromide; potassium acetate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1378431-20-9
methyl 2-bromo-5-vinylbenzoate

: 1378427-87-2
5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)ethyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen bromide / water / 2 h / 90 °C

2.1: potassium carbonate / acetonitrile / 24 h / 80 °C

3.1: potassium carbonate / acetonitrile / 3 h / 80 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 100 °C / Inert atmosphere

5.1: lithium borohydride / tetrahydrofuran / 2 h / 0 - 20 °C

5.2: Cooling with ice

With lithium borohydride; hydrogen bromide; potassium acetate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;