(S)-2-[2-(3,4-dimethyl-1H-phosphol-1-yl)phenyl]-4-isopropyl-4,5-dihydro-1,3-oxazole

Base Information

Chemical Name:(S)-2-[2-(3,4-dimethyl-1H-phosphol-1-yl)phenyl]-4-isopropyl-4,5-dihydro-1,3-oxazole
CAS No.:460990-86-7
Molecular Formula:C₁₈H₂₂NOP
Molecular Weight:299.353
Hs Code.:

Synonyms:(S)-2-[2-(3,4-dimethyl-1H-phosphol-1-yl)phenyl]-4-isopropyl-4,5-dihydro-1,3-oxazole

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Chemical Property of (S)-2-[2-(3,4-dimethyl-1H-phosphol-1-yl)phenyl]-4-isopropyl-4,5-dihydro-1,3-oxazole

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Technology Process of (S)-2-[2-(3,4-dimethyl-1H-phosphol-1-yl)phenyl]-4-isopropyl-4,5-dihydro-1,3-oxazole

There total 1 articles about (S)-2-[2-(3,4-dimethyl-1H-phosphol-1-yl)phenyl]-4-isopropyl-4,5-dihydro-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 30540-36-4
3,4-dimethyl-1-phenylphosphole

: 150255-47-3
(-)-(S)-2-(2-fluoro-phenyl)-4-isopropyl-4,5-dihydro-oxazole

: 460990-86-7
(S)-2-[2-(3,4-dimethyl-1H-phosphol-1-yl)phenyl]-4-isopropyl-4,5-dihydro-1,3-oxazole

Guidance literature:: With lithium; In tetrahydrofuran; at 45 ℃; for 48h;
DOI:10.1002/1099-0682(200207)2002:7<1657::AID-EJIC1657>3.0.CO;2-W

Reference yield: 85.0%

: 14040-11-0
tungsten hexacarbonyl

: 460990-86-7
(S)-2-[2-(3,4-dimethyl-1H-phosphol-1-yl)phenyl]-4-isopropyl-4,5-dihydro-1,3-oxazole

: (S)-2-[2-(3,4-dimethyl-1H-phosphol-1-yl)phenyl]-4-isopropyl-4,5-dihydro-1,3-oxazole

Guidance literature:: In tetrahydrofuran; Irradiation (UV/VIS); under N2, 1 equiv. of W-compd. in THF was irradiated by UV light for 30 min, P-compd. was added to this soln. in THF, stirring for 20 min; solvent was evapd., chromy. (silica gel, hexane:Et2O=24:1 to 9:1);
DOI:10.1002/1099-0682(200207)2002:7<1657::AID-EJIC1657>3.0.CO;2-W

Reference yield:

: 38117-54-3
cyclopentadienyl iron(II) dicarbonyl dimer

: 460990-86-7
(S)-2-[2-(3,4-dimethyl-1H-phosphol-1-yl)phenyl]-4-isopropyl-4,5-dihydro-1,3-oxazole

: 2-[2-[(S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl]phenyl]-3,4-dimethyl-1-phosphaferrocene

Guidance literature:: In toluene; 2 equiv. of P-compd. and carbonyl-compd. were heated at 160 °C for 4 h under 8 bar CO pressure, CO pressure was released, soln. was heated for 3 h; soln. was allowed to cool to room temp., detected by (31)P NMR, diastereomer ratio was 2:1;
DOI:10.1002/1099-0682(200207)2002:7<1657::AID-EJIC1657>3.0.CO;2-W