(6S)-6-[(3-bromobenzyl)oxy]-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol

Base Information

• Chemical Name: (6S)-6-[(3-bromobenzyl)oxy]-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol
• CAS No.: 1188390-61-5
• Molecular Formula: C₁₃H₁₂BrN₃O₄
• Molecular Weight: 354.16
• Mol file: 1188390-61-5.mol

Synonyms:(6S)-6-[(3-bromobenzyl)oxy]-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol

Chemical Property of (6S)-6-[(3-bromobenzyl)oxy]-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (6S)-6-[(3-bromobenzyl)oxy]-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol

There total 1 articles about (6S)-6-[(3-bromobenzyl)oxy]-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐ol (187235-08-1) + meta-bromobenzyl bromide (823-78-9) → (6S)-6-[(3-bromobenzyl)oxy]-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol (1188390-61-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 5 - 20 ℃;

DOI:10.1021/jm901207n

Reference yield: 61.0%

(6S)-6-[(3-bromobenzyl)oxy]-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol (1188390-61-5) + bis(pinacol)diborane (73183-34-3) → (6S)-2-nitro-6-{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (1198422-67-1)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In dimethyl sulfoxide; at 90 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm901207n

upstream raw materials:

(S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐ol

meta-bromobenzyl bromide

Downstream raw materials:

(6S)-2-nitro-6-{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine