Buformin hydrochloride

Base Information

• Chemical Name: Buformin hydrochloride
• CAS No.: 1190-53-0
• Molecular Formula: C6H15 N5 . Cl H
• Molecular Weight: 193.68
• Hs Code.: 29212900
• European Community (EC) Number: 239-587-5,214-723-6
• NSC Number: 528218,113665
• UNII: D947SXO87P
• DSSTox Substance ID: DTXSID50922844
• Wikidata: Q27276263
• NCI Thesaurus Code: C95329
• Mol file: 1190-53-0.mol

Synonyms:1 Butylbiguanide;1-Butylbiguanide;Adebit;Buformin;Butylbiguanide;Gliporal;Retard, Silubin;Silubin;Silubin Retard

Chemical Property of Buformin hydrochloride

Chemical Property:

• Vapor Pressure: 0.000275mmHg at 25°C
• Melting Point: 174-177ºC
• Boiling Point: 322.7 °C at 760 mmHg
• Flash Point: 148.9 °C
• PSA: 97.78000
• LogP: 2.27750
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 193.1094232
• Heavy Atom Count: 12
• Complexity: 156

Purity/Quality:

98%,99%, ^*data from raw suppliers

Buformin Hydrochloride ^*data from reagent suppliers

Safty Information:

• Statements: 22-43-36
• Safety Statements: 36/39-46

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCN=C(N)N=C(N)N.Cl
• Description: Buformin is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. It can also deactivate the glycolytic pathway by suppressing glyceraldehyde 3-phosphate dehydrogenase gene expression, which can lead to lactic acidosis. Biguanides, such as buformin, are reported to inhibit the mitochondrial respiratory complex I by inhibiting ubiquinone reduction and by stimulating reactive oxygen species production via the complex I flavin. Some biguanides, including buformin, can also inhibit the mitochondrial ATP synthase. Buformin has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.
• Uses: BuforMin Hydrochloride is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. BuforMin Hydrochloride has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells. Buformin, clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase.
• Therapeutic Function: Antidiabetic

Technology Process of Buformin hydrochloride

There total 1 articles about Buformin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ buformin hydrochloride (1190-53-0)

Guidance literature:

Reference yield:

buformin hydrochloride (1190-53-0) + p-toluenesulfonyl chloride (98-59-9) → 1-p-Toluolsulfonyl-5-butyl-biguanidin (4553-01-9)

Guidance literature:

With sodium hydroxide; In acetone;

Downstream raw materials:

1-p-Toluolsulfonyl-5-butyl-biguanidin

Refernces