N-[2-(1-dimethylamino-5,10-dioxo-1,4,5,10-tetrahydro-benzo[g]quinolin-4-yl)-phenyl]-2,2,2-trifluoro-acetamide

Base Information

Chemical Name:N-[2-(1-dimethylamino-5,10-dioxo-1,4,5,10-tetrahydro-benzo[g]quinolin-4-yl)-phenyl]-2,2,2-trifluoro-acetamide
CAS No.:250272-20-9
Molecular Formula:C₂₃H₁₈F₃N₃O₃
Molecular Weight:441.409
Hs Code.:

<i>N</i>-[2-(1-dimethylamino-5,10-dioxo-1,4,5,10-tetrahydro-benzo[<i>g</i>]quinolin-4-yl)-phenyl]-2,2,2-trifluoro-acetamide

Synonyms:N-[2-(1-dimethylamino-5,10-dioxo-1,4,5,10-tetrahydro-benzo[g]quinolin-4-yl)-phenyl]-2,2,2-trifluoro-acetamide

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Chemical Property of N-[2-(1-dimethylamino-5,10-dioxo-1,4,5,10-tetrahydro-benzo[g]quinolin-4-yl)-phenyl]-2,2,2-trifluoro-acetamide

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Technology Process of N-[2-(1-dimethylamino-5,10-dioxo-1,4,5,10-tetrahydro-benzo[g]quinolin-4-yl)-phenyl]-2,2,2-trifluoro-acetamide

There total 3 articles about N-[2-(1-dimethylamino-5,10-dioxo-1,4,5,10-tetrahydro-benzo[g]quinolin-4-yl)-phenyl]-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 407-25-0
trifluoroacetic anhydride

: (E)-N-[2-(3-N',N'-dimethylhydrazonoprop-1-enyl)phenyl]-2-amino-1,4-naphthoquinone

: 250272-20-9
N-[2-(1-dimethylamino-5,10-dioxo-1,4,5,10-tetrahydro-benzo[g]quinolin-4-yl)-phenyl]-2,2,2-trifluoro-acetamide

Guidance literature:: trifluoroacetic anhydride; (E)-N-[2-(3-N',N'-dimethylhydrazonoprop-1-enyl)phenyl]-2-amino-1,4-naphthoquinone; With sodium hydride; In tetrahydrofuran; at 23 ℃;

With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 1h;
DOI:10.1039/a905234h

Reference yield:

: 283152-35-2
o-aminocinnamaldehyde N,N-dimethylhydrazone

: 250272-20-9
N-[2-(1-dimethylamino-5,10-dioxo-1,4,5,10-tetrahydro-benzo[g]quinolin-4-yl)-phenyl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 70 percent / CeCl₃*7H₂O / methanol / 23 °C

2.1: NaH / tetrahydrofuran / 23 °C

2.2: 45 percent / TFA / CH₂Cl₂ / 1 h / 23 °C

With cerium(III) chloride; sodium hydride; In tetrahydrofuran; methanol; 1.1: Addition / 2.1: Acylation / 2.2: Cyclization;
DOI:10.1039/a905234h

Reference yield:

: 130-15-4
[1,4]naphthoquinone

: 250272-20-9
N-[2-(1-dimethylamino-5,10-dioxo-1,4,5,10-tetrahydro-benzo[g]quinolin-4-yl)-phenyl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 70 percent / CeCl₃*7H₂O / methanol / 23 °C

2.1: NaH / tetrahydrofuran / 23 °C

2.2: 45 percent / TFA / CH₂Cl₂ / 1 h / 23 °C

With cerium(III) chloride; sodium hydride; In tetrahydrofuran; methanol; 1.1: Addition / 2.1: Acylation / 2.2: Cyclization;
DOI:10.1039/a905234h