tert-butyl {(3R)-1-[4-(2-chlorobenzyl)-3-(hydrazinecarbonyl)-1H-pyrazol-5-yl]piperidin-3-yl}carbamate

Base Information

• Chemical Name: tert-butyl {(3R)-1-[4-(2-chlorobenzyl)-3-(hydrazinecarbonyl)-1H-pyrazol-5-yl]piperidin-3-yl}carbamate
• CAS No.: 847492-25-5
• Molecular Formula: C₂₁H₂₉ClN₆O₃
• Molecular Weight: 448.953

Synonyms:tert-butyl {(3R)-1-[4-(2-chlorobenzyl)-3-(hydrazinecarbonyl)-1H-pyrazol-5-yl]piperidin-3-yl}carbamate

Chemical Property of tert-butyl {(3R)-1-[4-(2-chlorobenzyl)-3-(hydrazinecarbonyl)-1H-pyrazol-5-yl]piperidin-3-yl}carbamate

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Technology Process of tert-butyl {(3R)-1-[4-(2-chlorobenzyl)-3-(hydrazinecarbonyl)-1H-pyrazol-5-yl]piperidin-3-yl}carbamate

There total 1 articles about tert-butyl {(3R)-1-[4-(2-chlorobenzyl)-3-(hydrazinecarbonyl)-1H-pyrazol-5-yl]piperidin-3-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-4-(2-chlorobenzyl)-1H-pyrazole-3-carboxylate (847492-26-6) → tert-butyl {(3R)-1-[4-(2-chlorobenzyl)-3-(hydrazinecarbonyl)-1H-pyrazol-5-yl]piperidin-3-yl}carbamate (847492-25-5)

Guidance literature:

With hydrazine; at 110 ℃; for 15h;

Reference yield:

tert-butyl {(3R)-1-[4-(2-chlorobenzyl)-3-(hydrazinecarbonyl)-1H-pyrazol-5-yl]piperidin-3-yl}carbamate (847492-25-5) + trifluoroacetic acid (76-05-1) → 2-[(3R)-3-aminopiperidin-1-yl]-3-(2-chlorobenzyl)-7-(trifluoromethyl)pyrazolo[1,5-d][1,2,4]triazin-4(5H)-one

Guidance literature:

With polyphosphoric acid; In tetrahydrofuran; at 140 ℃; for 16h;

Reference yield:

tert-butyl {(3R)-1-[4-(2-chlorobenzyl)-3-(hydrazinecarbonyl)-1H-pyrazol-5-yl]piperidin-3-yl}carbamate (847492-25-5) + trimethyl orthoformate (149-73-5) → tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-4-oxo-4,5-dihydropyrazolo[1,5-d][1,2,4]triazin-2-yl]piperidin-3-yl}carbamate (847492-24-4)

Guidance literature:

With acetic acid; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

upstream raw materials:

methyl 5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-4-(2-chlorobenzyl)-1H-pyrazole-3-carboxylate

Downstream raw materials:

tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-4-oxo-4,5-dihydropyrazolo[1,5-d][1,2,4]triazin-2-yl]piperidin-3-yl}carbamate

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