9-{(2R,4S,5S)-4-Azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purine-2,6-diamine

Base Information

Chemical Name:9-{(2R,4S,5S)-4-Azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purine-2,6-diamine
CAS No.:121513-04-0
Molecular Formula:C₃₀H₂₉N₉O₃
Molecular Weight:563.619
Hs Code.:

Synonyms:9-{(2R,4S,5S)-4-Azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purine-2,6-diamine

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Chemical Property of 9-{(2R,4S,5S)-4-Azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purine-2,6-diamine

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Technology Process of 9-{(2R,4S,5S)-4-Azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purine-2,6-diamine

There total 5 articles about 9-{(2R,4S,5S)-4-Azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purine-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 121513-03-9
(2R,3R,5R)-5-(2,6-Diamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-ol

: 121513-04-0
9-{(2R,4S,5S)-4-Azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purine-2,6-diamine

Guidance literature:: With lithium azide; carbon tetrabromide; triphenylphosphine; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1016/S0040-4039(01)80635-3

Reference yield:

: N²-isobutyryl-5'-O-benzoyl-2'-deoxyguanosine

: 121513-04-0
9-{(2R,4S,5S)-4-Azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purine-2,6-diamine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) trifluoromethanesulfonic anhydride; 2.) H₂O / 1.) dichloromethane, pyridine, 0 deg C, 30 min.; 2.) 7 h., room temp.

2: 90 percent / pyridine / 48 h / Ambient temperature

3: 1.) trifluoromethanesulfonic anhydride; 2.) ammonia / 1.) dichloromethane, pyridine, from -30 deg C to room temp., 1.5 h.; 2.) dioxane

4: methanolate / methanol / 10 h / 60 °C

5: 60 percent / triphenylphosphine, carbon tetrabromide, lithium azide / dimethylformamide / Ambient temperature

With lithium azide; carbon tetrabromide; methanolate; ammonia; water; trifluoromethanesulfonic acid anhydride; triphenylphosphine; In pyridine; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)80635-3

Reference yield:

: Benzoic acid (2R,3R,5R)-5-(6-amino-2-isobutylamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester

: 121513-04-0
9-{(2R,4S,5S)-4-Azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purine-2,6-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: methanolate / methanol / 10 h / 60 °C

2: 60 percent / triphenylphosphine, carbon tetrabromide, lithium azide / dimethylformamide / Ambient temperature

With lithium azide; carbon tetrabromide; methanolate; triphenylphosphine; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)80635-3