(2R,3R,5R)-5-(2,6-Diamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-ol

Base Information

• Chemical Name: (2R,3R,5R)-5-(2,6-Diamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-ol
• CAS No.: 121513-03-9
• Molecular Formula: C₃₀H₃₀N₆O₄
• Molecular Weight: 538.606
• Mol file: 121513-03-9.mol

Synonyms:(2R,3R,5R)-5-(2,6-Diamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-ol

Chemical Property of (2R,3R,5R)-5-(2,6-Diamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R,5R)-5-(2,6-Diamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-ol

There total 4 articles about (2R,3R,5R)-5-(2,6-Diamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzoic acid (2R,3R,5R)-5-(6-amino-2-isobutylamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester → (2R,3R,5R)-5-(2,6-Diamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-ol (121513-03-9)

Guidance literature:

With methanolate; In methanol; at 60 ℃; for 10h; Yield given;

DOI:10.1016/S0040-4039(01)80635-3

Reference yield:

N2-isobutyryl-5'-O-benzoyl-2'-deoxyguanosine → (2R,3R,5R)-5-(2,6-Diamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-ol (121513-03-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) trifluoromethanesulfonic anhydride; 2.) H₂O / 1.) dichloromethane, pyridine, 0 deg C, 30 min.; 2.) 7 h., room temp.

2: 90 percent / pyridine / 48 h / Ambient temperature

3: 1.) trifluoromethanesulfonic anhydride; 2.) ammonia / 1.) dichloromethane, pyridine, from -30 deg C to room temp., 1.5 h.; 2.) dioxane

4: methanolate / methanol / 10 h / 60 °C

With methanolate; ammonia; water; trifluoromethanesulfonic acid anhydride; In pyridine; methanol;

DOI:10.1016/S0040-4039(01)80635-3

Reference yield:

Benzoic acid (2R,3R,5R)-5-(2-isobutylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester → (2R,3R,5R)-5-(2,6-Diamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-ol (121513-03-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) trifluoromethanesulfonic anhydride; 2.) ammonia / 1.) dichloromethane, pyridine, from -30 deg C to room temp., 1.5 h.; 2.) dioxane

2: methanolate / methanol / 10 h / 60 °C

With methanolate; ammonia; trifluoromethanesulfonic acid anhydride; In methanol;

DOI:10.1016/S0040-4039(01)80635-3

Downstream raw materials:

9-{(2R,4S,5S)-4-Azido-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purine-2,6-diamine

9-(3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)-2,6-diaminopurine