Acetyl-(2,4,6-trimethylbenzoyl)-diazomethan

Base Information

• Chemical Name: Acetyl-(2,4,6-trimethylbenzoyl)-diazomethan
• CAS No.: 42797-59-1
• Molecular Formula: C₁₃H₁₄N₂O₂
• Molecular Weight: 230.266
• Mol file: 42797-59-1.mol

Synonyms:Acetyl-(2,4,6-trimethylbenzoyl)-diazomethan

Chemical Property of Acetyl-(2,4,6-trimethylbenzoyl)-diazomethan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Acetyl-(2,4,6-trimethylbenzoyl)-diazomethan

There total 2 articles about Acetyl-(2,4,6-trimethylbenzoyl)-diazomethan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-(2,4,6-trimethylphenyl)-1,3-butanedione (6450-57-3) → Acetyl-(2,4,6-trimethylbenzoyl)-diazomethan (42797-59-1)

Guidance literature:

With potassium fluoride; dibenzo-18-crown-6; 4-toluenesulfonyl azide; In dichloromethane; for 6h; Ambient temperature;

DOI:10.1055/s-1991-26416

Reference yield:

2,4,6-Trimethylacetophenone (1667-01-2,51885-97-3) → Acetyl-(2,4,6-trimethylbenzoyl)-diazomethan (42797-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / NaH, dibenzo-18-crown-6, ethanol / tetrahydrofuran / 1.) r.t, 0.5 h, 2.) reflux, 4 h

2: 72 percent / tosyl azide, KF*2H₂O, dibenzo-18-crown-6 / CH₂Cl₂ / 6 h / Ambient temperature

With potassium fluoride; dibenzo-18-crown-6; 4-toluenesulfonyl azide; ethanol; sodium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-1991-26416

upstream raw materials:

1-(2,4,6-trimethylphenyl)-1,3-butanedione

2,4,6-Trimethylacetophenone