(S)-4-[(S)-1-Hydroxy-2-benzyloxyethyl]-1,3-dioxolan-2-one

Base Information

Chemical Name:(S)-4-[(S)-1-Hydroxy-2-benzyloxyethyl]-1,3-dioxolan-2-one
CAS No.:78492-30-5
Molecular Formula:C₁₂H₁₄O₅
Molecular Weight:238.24
Hs Code.:
DSSTox Substance ID:DTXSID401152092
Nikkaji Number:J574.346J

Synonyms:DTXSID401152092;(S)-4-[(S)-1-Hydroxy-2-benzyloxyethyl]-1,3-dioxolan-2-one;1,3-Dioxolan-2-one, 4-[1-hydroxy-2-(phenylmethoxy)ethyl]-, [S-(R*,R*)]-;78492-30-5

Suppliers and Price of (S)-4-[(S)-1-Hydroxy-2-benzyloxyethyl]-1,3-dioxolan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-[(S)-1-Hydroxy-2-benzyloxyethyl]-1,3-dioxolan-2-one

Chemical Property:

XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:238.08412354
Heavy Atom Count:17
Complexity:249

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(OC(=O)O1)C(COCC2=CC=CC=C2)O
Isomeric SMILES:C1[C@H](OC(=O)O1)[C@H](COCC2=CC=CC=C2)O

Technology Process of (S)-4-[(S)-1-Hydroxy-2-benzyloxyethyl]-1,3-dioxolan-2-one

There total 10 articles about (S)-4-[(S)-1-Hydroxy-2-benzyloxyethyl]-1,3-dioxolan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 81028-07-1
(2S,3S)-1-(benzyloxy)butane-2,3,4-triol

: 78492-30-5
(2S,3S)-4-benzyloxy-1,2,3-butanetriol

Guidance literature:: With pyridine; In dichloromethane; at -70 ℃; for 0.25h;
DOI:10.1080/00397919408011189

Reference yield:

: 81028-06-0,81076-12-2
Phenyl-carbamic acid (2R,3S)-3-benzyloxymethyl-oxiranylmethyl ester

: 78492-30-5
(2S,3S)-4-benzyloxy-1,2,3-butanetriol

Guidance literature:: With perchloric acid; In acetonitrile; at 25 ℃; for 24h; Yield given;
DOI:10.1021/jo00346a051

Reference yield:

: 81028-03-7
(Z)-4-benzyloxy-but-2-en-1-ol

: 78492-30-5
(2S,3S)-4-benzyloxy-1,2,3-butanetriol

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / Ti(O-i-Pr)4, TBHP, (-)-DET / CH₂Cl₂ / 24 h / -20 °C

2: Et₃N / CH₂Cl₂ / 24 h / 25 °C

3: 5percent HClO₄ / acetonitrile / 24 h / 25 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; perchloric acid; (-)-diethyl tartrate; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jo00346a051