N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)acetimidamide

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Chemical Name:N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)acetimidamide
CAS No.:925216-54-2
Molecular Formula:C₂₄H₃₃N₅O
Molecular Weight:407.559
Hs Code.:

Synonyms:N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)acetimidamide

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Chemical Property of N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)acetimidamide

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Technology Process of N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)acetimidamide

There total 8 articles about N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)acetimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.2%

: thioacetimidic acid naphthalen-2-yl methyl ester hydrobromide

: 75821-80-6
1-[2-(diethylamino)ethyl]-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-amine

: 925216-54-2
N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)acetimidamide

Guidance literature:: thioacetimidic acid naphthalen-2-yl methyl ester hydrobromide; 1-[2-(diethylamino)ethyl]-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-amine; In ethanol; at 0 - 20 ℃; for 69h;

With sodium hydroxide; In water; ethyl acetate; pH=8 - 9;

Reference yield:

: 5099-39-8
N⁽¹⁾-(2-(diethylamino)ethyl)-4-nitrobenzene-1,2-diamine

: 925216-54-2
N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)acetimidamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 18 h / 35 °C / Inert atmosphere

2: phosphorus trichloride / chloroform / 4 h / Reflux; Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C

4: ethanol / 67 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; phosphorus trichloride; In ethanol; dichloromethane; chloroform;
DOI:10.1021/ml200268w

Reference yield:

: 56223-91-7
N’-(2,4-dinitrophenyl)-N,N-diethylethane-1,2-diamine

: 925216-54-2
N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)acetimidamide

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium sulfide / ethanol; water / 2.5 h / 65 - 70 °C / Inert atmosphere

2: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 18 h / 35 °C / Inert atmosphere

3: phosphorus trichloride / chloroform / 4 h / Reflux; Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C

5: ethanol / 67 h / 20 °C / Inert atmosphere

With ammonium sulfide; palladium 10% on activated carbon; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; phosphorus trichloride; In ethanol; dichloromethane; chloroform; water; 1: Zinin reduction;
DOI:10.1021/ml200268w