75821-80-6

Basic information

• Product Name: 1-[2-(diethylamino)ethyl]-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-amine
• Synonyms: 1-[2-(diethylamino)ethyl]-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-amine
• CAS NO: 75821-80-6
• Molecular Weight: 366.506
• Mol File: 75821-80-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-[2-(diethylamino)ethyl]-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(diethylamino)ethyl]-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-amine(75821-80-6)
• EPA Substance Registry System: 1-[2-(diethylamino)ethyl]-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-amine(75821-80-6)

Safety Data

• Hazardous Substances Data: 75821-80-6(Hazardous Substances Data)

Usage

General Description

The chemical 1-[2-(diethylamino)ethyl]-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-amine is a complex organic compound with a long molecular structure. It contains an imidazole ring and a benzyl group, as well as a diethylaminoethyl moiety. The compound also has an ethoxy group attached to the benzyl group. This chemical may have potential pharmaceutical or biological applications due to the presence of the imidazole and amine functional groups, which are often found in drugs and bioactive compounds. Its specific properties and uses would need to be further investigated through research and testing.

Upstream product

• 2053-25-0 etonitazone hydrochloride 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 100-36-7 N,N-diethylethylenediamine 
• 55154-71-7 N-[2-{(2-(diethylamino)ethyl)amino}-5-nitrophenyl]-2-(4-ethoxyphenyl)acetamide 
• 56223-91-7 N’-(2,4-dinitrophenyl)-N,N-diethylethane-1,2-diamine 
• 5099-39-8 N⁽¹⁾-(2-(diethylamino)ethyl)-4-nitrobenzene-1,2-diamine 
• 911-65-9 etonitazene 
• 128659-81-4 1-<2-(N,N-diethylamino)ethyl>-2-(p-ethoxybenzyl)-5-benzimidazole 

Downstream Products

• 128659-81-4 1-<2-(N,N-diethylamino)ethyl>-2-(p-ethoxybenzyl)-5-benzimidazole 
• 118409-77-1 etonitazenediazonium 
• 925216-51-9 N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)thiophen-2-carboximidamide 
• 925216-62-2 1-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)-3-nitroguanidine 
• 925216-66-6 N-(1-(2-(diethylamino)ethyl-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)carbamothiolyl)benzamide 
• 925216-58-6 N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)furan-2-carboximidamide 
• 925216-65-5 N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)thiophen-3-carboximidamide 
• 925216-60-0 N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)furan-3-carboximidamide 
• 925216-54-2 N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)acetimidamide 

Relevant articles and documents

Synthesis and molecular docking for antiinflammatory studies of 2-(arylmethyl)-1-ethyl-1H-benzo[d]imidazol-5-amines

1-Chloro-2,4-dinitrobenzene (1) was reacted with aliphatic amines (2) in ethanol as solvent under reflux condition for 16-24 h to form N-alkyl-2,4-dinitroaniline (3). Compound 3 undergoes reduction to from N-alkyl-4-nitrobenzene-1,2-diamine (4). Compound 4 was treated with carboxylic acid (5) to offered N-(2-(alkylamino)-5-nitrophenyl)-2-arylacetamide (6) which on cyclization gave 2-(arylmethyl)-1-ethyl-5-nitro-1H-benzo[d]imidazole (7). Finally, compound 7 undergoes reduction give 2-(arylmethyl)-1-ethyl-1H-benzo[d]imidazol-5-amine (8). The synthesized compounds were characterized by using spectral analyses. The compounds synthesized were confirmed by spectral analyses. Molecular docking of 5COX with the ligand using docking server, predicted the compound to be a potential anti-inflammatory compound.

Substituted benzimidazole compounds with dual NOS inhibitory activity and mu opioid agonist activity

The present invention relates to benzimidazole compounds having dual nitric oxide synthase (NOS) inhibitory activity and agonist activity at the mu-opioid receptor, to pharmaceutical and diagnostic compositions containing them, and to their medical use, particularly as compounds for the treatment or prevention of chronic pain, acute pain, migraine, and neuropathic pain.