(S)-(2-(hydroxymethyl)-2,3-dihydro-1H-pyrrol-1-yl)(2-nitrophenyl)methanone

Base Information

Chemical Name:(S)-(2-(hydroxymethyl)-2,3-dihydro-1H-pyrrol-1-yl)(2-nitrophenyl)methanone
CAS No.:135159-16-9
Molecular Formula:C₁₂H₁₂N₂O₄
Molecular Weight:248.238
Hs Code.:

Synonyms:(S)-(2-(hydroxymethyl)-2,3-dihydro-1H-pyrrol-1-yl)(2-nitrophenyl)methanone

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Chemical Property of (S)-(2-(hydroxymethyl)-2,3-dihydro-1H-pyrrol-1-yl)(2-nitrophenyl)methanone

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Technology Process of (S)-(2-(hydroxymethyl)-2,3-dihydro-1H-pyrrol-1-yl)(2-nitrophenyl)methanone

There total 7 articles about (S)-(2-(hydroxymethyl)-2,3-dihydro-1H-pyrrol-1-yl)(2-nitrophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 135159-19-2
(S)-(2-(((tert-butyldimethylsilyl)oxy)methyl)-2,3-dihydro-1H-pyrrol-1-yl)(2-nitrophenyl)methanone

: 135159-16-9
(S)-(2-(hydroxymethyl)-2,3-dihydro-1H-pyrrol-1-yl)(2-nitrophenyl)methanone

Guidance literature:: With camphor-10-sulfonic acid; In methanol; dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jacs.6b03373

Reference yield: 30.0%

: 105308-69-8
((2S,5S)-2-Hydroxymethyl-5-methoxy-pyrrolidin-1-yl)-(2-nitro-phenyl)-methanone

: 135159-16-9
(S)-(2-(hydroxymethyl)-2,3-dihydro-1H-pyrrol-1-yl)(2-nitrophenyl)methanone

Guidance literature:: at 160 ℃; reduced pressure;
DOI:10.1016/S0040-4039(00)79689-4

Reference yield:

: 106191-02-0
(S)-5-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-2-one

: 135159-16-9
(S)-(2-(hydroxymethyl)-2,3-dihydro-1H-pyrrol-1-yl)(2-nitrophenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride; potassium iodide / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C / Inert atmosphere

1.2: 0.17 h / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.1: lithium chloride; triphenylphosphine; palladium diacetate; tri-n-butyl-tin hydride / tetrahydrofuran / 0.17 h / Inert atmosphere

4.1: camphor-10-sulfonic acid / methanol; dichloromethane / 1 h / 20 °C / Inert atmosphere

With camphor-10-sulfonic acid; tri-n-butyl-tin hydride; palladium diacetate; sodium hydride; triphenylphosphine; potassium iodide; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; mineral oil;
DOI:10.1021/jacs.6b03373