((2S,5S)-2-Hydroxymethyl-5-methoxy-pyrrolidin-1-yl)-(2-nitro-phenyl)-methanone

Base Information

Chemical Name:((2S,5S)-2-Hydroxymethyl-5-methoxy-pyrrolidin-1-yl)-(2-nitro-phenyl)-methanone
CAS No.:105308-69-8
Molecular Formula:C₁₃H₁₆N₂O₅
Molecular Weight:280.28
Hs Code.:

Synonyms:((2S,5S)-2-Hydroxymethyl-5-methoxy-pyrrolidin-1-yl)-(2-nitro-phenyl)-methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((2S,5S)-2-Hydroxymethyl-5-methoxy-pyrrolidin-1-yl)-(2-nitro-phenyl)-methanone

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Technology Process of ((2S,5S)-2-Hydroxymethyl-5-methoxy-pyrrolidin-1-yl)-(2-nitro-phenyl)-methanone

There total 18 articles about ((2S,5S)-2-Hydroxymethyl-5-methoxy-pyrrolidin-1-yl)-(2-nitro-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 105308-69-8
((2S,5S)-2-Hydroxymethyl-5-methoxy-pyrrolidin-1-yl)-(2-nitro-phenyl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

2: 1.) NaH, KI / 1.) THF

3: diisobutyl-aluminium / -70 °C

4: TsOH / H₂O; tetrahydrofuran / 20 °C

With sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; potassium iodide; In tetrahydrofuran; water;
DOI:10.1016/S0040-4039(00)84202-1

Reference yield:

: 67-56-1
methanol

: 105243-50-3
(5S)-5-(1-ethoxy-ethoxymethyl)-1-(2-nitro-benzoyl)-pyrrolidin-2-ol

: 105308-69-8
((2S,5S)-2-Hydroxymethyl-5-methoxy-pyrrolidin-1-yl)-(2-nitro-phenyl)-methanone

: 105308-70-1
((2S,5R)-2-Hydroxymethyl-5-methoxy-pyrrolidin-1-yl)-(2-nitro-phenyl)-methanone

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; water; at 20 ℃; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4039(00)84202-1

Reference yield:

: 610-14-0
2-nitrobenzyl chloride

: 104783-97-3,104783-98-4,105308-69-8,105308-70-1,112459-04-8,112459-05-9
N-(o-nitrobenzoyl)-5-hydroxymethyl-2-methoxypyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) triethylamine / 1.) CH₂Cl₂, RT, 20 min, 2.) 20 deg C, 75 min

2: 53 percent / NaBH₄ / methanol / 1 h / 20 °C

3: 100 percent / m-chloroperbenzoic acid, sodium carbonate / 1,2-dichloro-ethane / 30 h / Ambient temperature

4: 46 percent / NaH / benzene / 2.5 h / 20 °C

With sodium tetrahydroborate; sodium hydride; sodium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; 1,2-dichloro-ethane; benzene;
DOI:10.3987/R-1986-03-0777