2-(5-methoxy-2-oxoindolin-3-ylidene)malononitrile

Base Information

• Chemical Name: 2-(5-methoxy-2-oxoindolin-3-ylidene)malononitrile
• CAS No.: 848924-85-6
• Molecular Formula: C₁₂H₇N₃O₂
• Molecular Weight: 225.206
• Mol file: 848924-85-6.mol

Synonyms:2-(5-methoxy-2-oxoindolin-3-ylidene)malononitrile

Chemical Property of 2-(5-methoxy-2-oxoindolin-3-ylidene)malononitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(5-methoxy-2-oxoindolin-3-ylidene)malononitrile

There total 1 articles about 2-(5-methoxy-2-oxoindolin-3-ylidene)malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

5-methoxyindolin-2-one (7699-18-5) + malononitrile (109-77-3) → 2-(5-methoxy-2-oxoindolin-3-ylidene)malononitrile (848924-85-6)

Guidance literature:

With iron(III) chloride hexahydrate; oxygen; In N,N-dimethyl-formamide; at 50 ℃; for 5h; Green chemistry;

DOI:10.1039/c9gc03639c

Reference yield: 99.0%

2-(5-methoxy-2-oxoindolin-3-ylidene)malononitrile (848924-85-6) + 1-Phenylbut-1-en-3-one (122-57-6) → 5'-methoxy-2',5-dioxo-3-phenylspiro[cyclohexane-1,3'-indoline]-2,2-dicarbonitrile (1332338-80-3)

Guidance literature:

With C₂₀H₂₅N₃O; (R)-1,1'-binaphthyl-2,2'-phosphoric acid; In 1,2-dichloro-ethane; at 80 ℃; for 2h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol201943g

Reference yield: 99.0%

2-(5-methoxy-2-oxoindolin-3-ylidene)malononitrile (848924-85-6) + 1-benzyl-3-fluoroindolin-2-one → 2-(1-benzyl-3-fluoro-5'-methoxy-2,2'-dioxo-[3,3'-biindolin]-3'-yl)malononitrile

Guidance literature:

With triethylamine; In ethanol; water; at 25 ℃; for 8h; diastereoselective reaction; Sonication; Green chemistry;

DOI:10.1002/adsc.201701107

upstream raw materials:

5-methoxyindolin-2-one

malononitrile

Downstream raw materials:

5'-methoxy-2',5-dioxo-3-phenylspiro[cyclohexane-1,3'-indoline]-2,2-dicarbonitrile