7699-18-5

Basic information

• Product Name: 5-METHOXYOXINDOLE
• Synonyms: 5-METHOXYOXINDOLE;5-METHOXY-1,3-DIHYDRO-INDOL-2-ONE;5-METHOXYINDOLIN-2-ONE;5-Methoxy-1,3-dihydro-2H-indol-2-one;5-Methylindolin-2-one;5-Methoxy-2-oxindole;5-(Methylperoxy)-1H-indole;5-Methoxy-2-oxyindole
• CAS NO: 7699-18-5
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17
• Product Categories: pharmacetical;Indoline & Oxindole
• Mol File: 7699-18-5.mol
• Article Data: 57

Chemical Properties

• Melting Point: 152-154 °C
• Boiling Point: 360.7 °C at 760 mmHg
• Flash Point: 172 °C
• Appearance: /
• Density: 1.208 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.66±0.20(Predicted)
• CAS DataBase Reference: 5-METHOXYOXINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXYOXINDOLE(7699-18-5)
• EPA Substance Registry System: 5-METHOXYOXINDOLE(7699-18-5)

Safety Data

• Hazardous Substances Data: 7699-18-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 25, p. 1279, 1988 DOI: 10.1002/jhet.5570250501Tetrahedron Letters, 30, p. 715, 1989 DOI: 10.1016/S0040-4039(01)80290-2

InChI:InChI:1S/C9H9NO2/c1-12-7-2-3-8-6(4-7)5-9(11)10-8/h2-4H,5H2,1H3,(H,10,11)

Upstream product

• 65816-14-0 1-methoxyindolin-2-one 
• 121726-57-6 N-Acetoxy-2-(3-methoxy-phenyl)-acetamide 
• 39755-95-8 5-methoxyisatine 
• 1006-94-6 5-methoxylindole 
• 3416-18-0 5-hydroxyoxindole 
• 77-78-1 dimethyl sulfate 
• 20876-29-3 2-(5-methoxy-2-nitrophenyl)acetic acid 
• 27387-22-0 2-(2-bromo-5-methoxyphenyl)acetamide 
• 27387-23-1 5-methoxy-2-bromophenylacetonitrile 
• 638563-46-9 C₉H₉N₃O₂ 
• 6335-41-7 2-hydroxyimino-N-(4-methoxyphenyl)acetamide 
• 1798-09-0 m-methoxyphenylacetic acid 
• 18463-71-3 3-methoxyphenylacetamide 
• 888030-06-6 2-(2-iodo-5-methoxyphenyl)acetamide 

Downstream Products

• 141946-38-5 5-Methoxy-3-[1-pyridin-3-yl-meth-(E)-ylidene]-1,3-dihydro-indol-2-one 
• 141946-38-5 5-Methoxy-3-[1-pyridin-3-yl-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one 
• 141946-39-6 5-Methoxy-3-[1-(6-methyl-pyridin-2-yl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one 
• 120109-86-6 5-Methoxy-2-oxo-2,3-dihydro-indole-1-carboxylic acid (4-chloro-phenyl)-amide 
• 73424-96-1 5-methoxyindoline-2-thione 
• 119730-01-7 2-chloro-5-methoxy-1H-indole 
• 222533-48-4 5-methoxy-3-(3-methylbut-2-enyl)-2-oxindole 
• 374898-41-6 tert-butyl 5-methoxy-2-oxoindoline-1-carboxylate 

Relevant articles and documents

A Unified Catalytic Asymmetric (4+1) and (5+1) Annulation Strategy to Access Chiral Spirooxindole-Fused Oxacycles

A unified catalytic asymmetric (N+1) (N=4, 5) annulation reaction of oxindoles with bifunctional peroxides has been achieved in the presence of a chiral phase-transfer catalyst (PTC). This general strategy utilizes peroxides as unique bielectrophilic four- or five-atom synthons to participate in the C?C and the subsequent umpolung C?O bond-forming reactions with one-carbon unit nucleophiles, thus providing a distinct method to access the valuable chiral spirooxindole-tetrahydrofurans and -tetrahydropyrans with good yields and high enantioselectivities under mild conditions. DFT calculations were performed to rationalize the origin of high enantioselectivity. The gram-scale syntheses and synthetic utility of the resultant products were also demonstrated.

METHOD FOR PRODUCING LACTAM COMPOUND, AND LACTAM COMPOUND PRODUCED THEREBY

The present invention relates to a method for producing a lactam compound from dioxazolone in the presence of a catalyst having a particular ligand, and to a lactam compound produced thereby, and can produce a lactam compound with excellent selectivity and an excellent yield by using the combination of a starting material having a particular functional group and a particular catalyst having a particular ligand.

Synthesis of Functionalized Indolines and Dihydrobenzofurans by Iron and Copper Catalyzed Aryl C-N and C-O Bond Formation

A simple and effective one-pot, two-step intramolecular aryl C-N and C-O bond forming process for the preparation of a wide range of benzo-fused heterocyclic scaffolds using iron and copper catalysis is described. Activated aryl rings were subjected to a highly regioselective, iron(III) triflimide-catalyzed iodination, followed by a copper(I)-catalyzed intramolecular N-or O-arylation step leading to indolines, dihydrobenzofurans, and six-membered analogues. The general applicability and functional group tolerance of this method were exemplified by the total synthesis of the neolignan natural product, (+)-obtusafuran. DFT calculations using Fukui functions were also performed, providing a molecular orbital rationale for the highly regioselective arene iodination process.