4-(1-Benzyl-4-nitro-imidazol-5-yl)-2,6-dimethyl-pyridin-3,5-dicarbonsaeuredimethylester

Base Information

• Chemical Name: 4-(1-Benzyl-4-nitro-imidazol-5-yl)-2,6-dimethyl-pyridin-3,5-dicarbonsaeuredimethylester
• CAS No.: 256530-68-4
• Molecular Formula: C₂₁H₂₀N₄O₆
• Molecular Weight: 424.413
• Mol file: 256530-68-4.mol

Synonyms:4-(1-Benzyl-4-nitro-imidazol-5-yl)-2,6-dimethyl-pyridin-3,5-dicarbonsaeuredimethylester

Chemical Property of 4-(1-Benzyl-4-nitro-imidazol-5-yl)-2,6-dimethyl-pyridin-3,5-dicarbonsaeuredimethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1-Benzyl-4-nitro-imidazol-5-yl)-2,6-dimethyl-pyridin-3,5-dicarbonsaeuredimethylester

There total 3 articles about 4-(1-Benzyl-4-nitro-imidazol-5-yl)-2,6-dimethyl-pyridin-3,5-dicarbonsaeuredimethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(1-Benzyl-4-nitro-imidazol-5-yl)-1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarbonsaeuredimethylester (154926-96-2) → 4-(1-Benzyl-4-nitro-imidazol-5-yl)-2,6-dimethyl-pyridin-3,5-dicarbonsaeuredimethylester (256530-68-4)

Guidance literature:

With cerium(IV) ammonium nitrate; In acetone; at 20 ℃; for 0.333333h;

Reference yield:

methyl 3-aminocrotonate (21731-17-9) → 4-(1-Benzyl-4-nitro-imidazol-5-yl)-2,6-dimethyl-pyridin-3,5-dicarbonsaeuredimethylester (256530-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / acetic acid / 22 h / 20 - 60 °C

2: 90 percent / aq. [(NH₄)2Ce](NO₃)6 / acetone / 0.33 h / 20 °C

With cerium(IV) ammonium nitrate; In acetic acid; acetone; 1: cyclocondensation; Hantzsch synthesis / 2: Dehydrogenation;

Reference yield:

3-benzyl-5-nitro-3H-imidazole-4-carbaldehyde (154927-05-6) → 4-(1-Benzyl-4-nitro-imidazol-5-yl)-2,6-dimethyl-pyridin-3,5-dicarbonsaeuredimethylester (256530-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / acetic acid / 22 h / 20 - 60 °C

2: 90 percent / aq. [(NH₄)2Ce](NO₃)6 / acetone / 0.33 h / 20 °C

With cerium(IV) ammonium nitrate; In acetic acid; acetone; 1: cyclocondensation; Hantzsch synthesis / 2: Dehydrogenation;

upstream raw materials:

4-(1-Benzyl-4-nitro-imidazol-5-yl)-1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarbonsaeuredimethylester

methyl 3-aminocrotonate

3-benzyl-5-nitro-3H-imidazole-4-carbaldehyde