6-fluoro-2-tert-butyl-4-benzooxazolyl-5'-methyl-3'-pyridylcarbinol

Base Information

Chemical Name:6-fluoro-2-tert-butyl-4-benzooxazolyl-5'-methyl-3'-pyridylcarbinol
CAS No.:114995-66-3
Molecular Formula:C₁₈H₁₉FN₂O₂
Molecular Weight:314.359
Hs Code.:

6-fluoro-2-tert-butyl-4-benzo<c>oxazolyl-5'-methyl-3'-pyridylcarbinol

Synonyms:6-fluoro-2-tert-butyl-4-benzooxazolyl-5'-methyl-3'-pyridylcarbinol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-fluoro-2-tert-butyl-4-benzooxazolyl-5'-methyl-3'-pyridylcarbinol

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Technology Process of 6-fluoro-2-tert-butyl-4-benzooxazolyl-5'-methyl-3'-pyridylcarbinol

There total 2 articles about 6-fluoro-2-tert-butyl-4-benzooxazolyl-5'-methyl-3'-pyridylcarbinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 444-14-4
2-bromo-4,6-difluoroaniline

: 114995-66-3
6-fluoro-2-tert-butyl-4-benzooxazolyl-5'-methyl-3'-pyridylcarbinol

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / CHCl₃ / 1.) RT, 15 min, 2.) reflux, 3 h, 3.) RT, overnight

2: 1.) 2.4 M n-butyllithium / 1.) a.) THF, hexane, -100 deg C, 15 min, b.) from -100 deg C to 0 deg C, 2.) -78 deg C, 30 min

With n-butyllithium; In chloroform;
DOI:10.1021/jo00250a019

Reference yield:

: 100910-66-5
5-methyl-3-pyridinecarboxaldehyde

: 114995-48-1
N-(2-bromo-4,6-difluorophenyl)pivalamide

: 114995-66-3
6-fluoro-2-tert-butyl-4-benzooxazolyl-5'-methyl-3'-pyridylcarbinol

: N-{2,4-Difluoro-6-[hydroxy-(5-methyl-pyridin-3-yl)-methyl]-phenyl}-2,2-dimethyl-propionamide

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction. Yields of byproduct given; 1.) a.) THF, hexane, -100 deg C, 15 min, b.) from -100 deg C to 0 deg C, 2.) -78 deg C, 30 min;
DOI:10.1021/jo00250a019