N-(2-Bromo-4,6-difluorophenyl)pivalamide

Base Information

Chemical Name:N-(2-Bromo-4,6-difluorophenyl)pivalamide
CAS No.:114995-48-1
Molecular Formula:C₁₁H₁₂BrF₂NO
Molecular Weight:292.123
Hs Code.:
DSSTox Substance ID:DTXSID101207509

Synonyms:N-(2-Bromo-4,6-difluorophenyl)pivalamide;114995-48-1;SCHEMBL8188784;JRPFMFXMDNQTTB-UHFFFAOYSA-N;DTXSID101207509;AKOS008919353;N-(2-Bromo-4,6-Difluorophenyl) Pivalamide;N-(2-bromo-4,6-difluorophenyl)-2,2-dimethylpropanamide

Suppliers and Price of N-(2-Bromo-4,6-difluorophenyl)pivalamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-Bromo-4,6-difluorophenyl)pivalamide

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:291.00703
Heavy Atom Count:16
Complexity:267

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)C(=O)NC1=C(C=C(C=C1Br)F)F

Technology Process of N-(2-Bromo-4,6-difluorophenyl)pivalamide

There total 2 articles about N-(2-Bromo-4,6-difluorophenyl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 444-14-4
2-bromo-4,6-difluoroaniline

: 3282-30-2
pivaloyl chloride

: 114995-48-1
N-(2-bromo-4,6-difluorophenyl)pivalamide

Guidance literature:: In chloroform; 1.) RT, 15 min, 2.) reflux, 3 h, 3.) RT, overnight;
DOI:10.1021/jo00250a019

Reference yield:

: 1122-58-3
dmap

: 444-14-4
2-bromo-4,6-difluoroaniline

: 3282-30-2
pivaloyl chloride

: 114995-48-1
N-(2-bromo-4,6-difluorophenyl)pivalamide

Guidance literature:: With pyridine; sodium hydrogencarbonate; In diethyl ether; dichloromethane;

Reference yield:

: 114995-48-1
N-(2-bromo-4,6-difluorophenyl)pivalamide

: 114995-57-2
(2-Amino-3,5-difluoro-phenyl)-phenyl-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 3.40 M n-butyllithium / 1.) THF, hexane, -100 deg C, 45 min, 2.) RT, overnight

2: 100 percent / pyridinium chlorochromate / CH₂Cl₂

3: 70percent aq. sulfuric acid / 95 - 100 °C

With n-butyllithium; sulfuric acid; pyridinium chlorochromate; In dichloromethane;
DOI:10.1021/jo00250a019