1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-4-(2-{[4-(methylsulfonyl)phenyl]sulfonyl}ethyl)piperidine hydrochloride

Base Information

Chemical Name:1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-4-(2-{[4-(methylsulfonyl)phenyl]sulfonyl}ethyl)piperidine hydrochloride
CAS No.:718610-47-0
Molecular Formula:C₃₀H₃₅F₂NO₆S₃*ClH
Molecular Weight:676.267
Hs Code.:

Synonyms:1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-4-(2-{[4-(methylsulfonyl)phenyl]sulfonyl}ethyl)piperidine hydrochloride

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Chemical Property of 1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-4-(2-{[4-(methylsulfonyl)phenyl]sulfonyl}ethyl)piperidine hydrochloride

Chemical Property:

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Technology Process of 1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-4-(2-{[4-(methylsulfonyl)phenyl]sulfonyl}ethyl)piperidine hydrochloride

There total 6 articles about 1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-4-(2-{[4-(methylsulfonyl)phenyl]sulfonyl}ethyl)piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 718610-20-9
1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-4-(2-{[4-(methylsulfonyl)phenyl]sulfonyl}ethyl)piperidine

: 718610-47-0
1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-4-(2-{[4-(methylsulfonyl)phenyl]sulfonyl}ethyl)piperidine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol; at 20 ℃; for 16h;

Reference yield:

: 1122-97-0
4-methylsulfanyl-thiophenol

: 718610-47-0
1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-4-(2-{[4-(methylsulfonyl)phenyl]sulfonyl}ethyl)piperidine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 0 °C

1.2: 16 h / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h

4.1: dichloromethane / 0.5 h / 20 °C

4.2: 1 h

5.1: hydrogenchloride / 1,4-dioxane; ethanol / 16 h / 20 °C

With hydrogenchloride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane;

Reference yield:

: 718610-54-9
N-tert-butoxycarbonyl-4-[2-(4-methylsulphonylphenylsulphonyl)ethyl]-piperidine

: 718610-47-0
1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-4-(2-{[4-(methylsulfonyl)phenyl]sulfonyl}ethyl)piperidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h

2.1: dichloromethane / 0.5 h / 20 °C

2.2: 1 h

3.1: hydrogenchloride / 1,4-dioxane; ethanol / 16 h / 20 °C

With hydrogenchloride; In 1,4-dioxane; ethanol; dichloromethane;