N-[1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]-4(S),5(S)-dihydroxy-6-phenyl-2(R)-[[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]hexanamide

Base Information

Chemical Name:N-[1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]-4(S),5(S)-dihydroxy-6-phenyl-2(R)-[[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]hexanamide
CAS No.:220588-90-9
Molecular Formula:C₄₉H₆₁N₃O₅
Molecular Weight:772.04
Hs Code.:

Synonyms:N-[1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]-4(S),5(S)-dihydroxy-6-phenyl-2(R)-[[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]hexanamide

Suppliers and Price of N-[1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]-4(S),5(S)-dihydroxy-6-phenyl-2(R)-[[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]hexanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]-4(S),5(S)-dihydroxy-6-phenyl-2(R)-[[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]hexanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]-4(S),5(S)-dihydroxy-6-phenyl-2(R)-[[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]hexanamide

There total 17 articles about N-[1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]-4(S),5(S)-dihydroxy-6-phenyl-2(R)-[[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 220588-89-6
4(S),5(S)-bis[(tert-butyldimethylsilyl)oxy]-N-[1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]-6-phenyl-2(R)-[[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]hexanamide

: 220588-90-9
N-[1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]-4(S),5(S)-dihydroxy-6-phenyl-2(R)-[[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]hexanamide

Guidance literature:: With hydrogen fluoride; In acetonitrile; at 20 ℃; for 1.8h;
DOI:10.1016/S0968-0896(98)80011-4

Reference yield:

: 6052-66-0,112370-40-8,123877-73-6
1-phenyl-3-buten-2-ol

: 220588-90-9
N-[1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]-4(S),5(S)-dihydroxy-6-phenyl-2(R)-[[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]hexanamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: 1,5-hexadiene; SOBr₂ / 1,2-dichloro-ethane / 1.5 h / 0 °C

2.1: NaHMDS / tetrahydrofuran / 1 h / -78 °C

2.2: 48 percent / tetrahydrofuran / 3.5 h / -78 °C

3.1: NMMO*H₂O / OsO₄ / tetrahydrofuran; H₂O / 1 h / 25 °C

4.1: H₂O₂; LiOH*H₂O / tetrahydrofuran; H₂O / 0.75 h / 0 °C

5.1: 2.74 g / TFA / tetrahydrofuran / 3.75 h / 0 °C

6.1: 34 percent / Et₃N; DMAP / CH₂Cl₂ / 2.2 h / 0 °C

7.1: LiOH*H₂O / tetrahydrofuran; H₂O / 15 h / 25 °C

7.2: 2,6-lutidine / dimethylformamide / 1.5 h / 0 °C

8.1: 0.80 g / aq. NaOH / tetrahydrofuran / 1 h / 0 °C

9.1: 0.76 g / i-Pr₂NEt; BOP*PF₆ / CH₂Cl₂ / 1.7 h / 20 °C

10.1: 79 percent / aq. HF / acetonitrile / 1.8 h / 20 °C

With dmap; lithium hydroxide; sodium hydroxide; sulfurous dibromide; 1,5-Hexadien; NMMO*H₂O; hydrogen fluoride; dihydrogen peroxide; sodium hexamethyldisilazane; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; osmium(VIII) oxide; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile; 1.1: Substitution / 2.1: Metallation / 2.2: Evans' alkylation / 3.1: Oxidation / 4.1: Hydrolysis / 5.1: Cyclization / 6.1: Esterification / 7.1: Hydrolysis / 7.2: silylation / 8.1: Hydrolysis / 9.1: Acylation / 10.1: Hydrolysis;
DOI:10.1016/S0968-0896(98)80011-4

Reference yield:

: 40734-75-6
(E)-(4-bromobut-2-en-1-yl)benzene

: 220588-90-9
N-[1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]-4(S),5(S)-dihydroxy-6-phenyl-2(R)-[[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]hexanamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: NaHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: 48 percent / tetrahydrofuran / 3.5 h / -78 °C

2.1: NMMO*H₂O / OsO₄ / tetrahydrofuran; H₂O / 1 h / 25 °C

3.1: H₂O₂; LiOH*H₂O / tetrahydrofuran; H₂O / 0.75 h / 0 °C

4.1: 2.74 g / TFA / tetrahydrofuran / 3.75 h / 0 °C

5.1: 34 percent / Et₃N; DMAP / CH₂Cl₂ / 2.2 h / 0 °C

6.1: LiOH*H₂O / tetrahydrofuran; H₂O / 15 h / 25 °C

6.2: 2,6-lutidine / dimethylformamide / 1.5 h / 0 °C

7.1: 0.80 g / aq. NaOH / tetrahydrofuran / 1 h / 0 °C

8.1: 0.76 g / i-Pr₂NEt; BOP*PF₆ / CH₂Cl₂ / 1.7 h / 20 °C

9.1: 79 percent / aq. HF / acetonitrile / 1.8 h / 20 °C

With dmap; lithium hydroxide; sodium hydroxide; NMMO*H₂O; hydrogen fluoride; dihydrogen peroxide; sodium hexamethyldisilazane; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; osmium(VIII) oxide; In tetrahydrofuran; dichloromethane; water; acetonitrile; 1.1: Metallation / 1.2: Evans' alkylation / 2.1: Oxidation / 3.1: Hydrolysis / 4.1: Cyclization / 5.1: Esterification / 6.1: Hydrolysis / 6.2: silylation / 7.1: Hydrolysis / 8.1: Acylation / 9.1: Hydrolysis;
DOI:10.1016/S0968-0896(98)80011-4