alpha-Ethenylbenzeneethanol

Base Information

• Chemical Name: alpha-Ethenylbenzeneethanol
• CAS No.: 6052-66-0
• Molecular Formula: C10H12O
• Molecular Weight: 148.20200
• Mol file: 6052-66-0.mol

Synonyms:(2RS)-1-phenyl-3-buten-2-ol;(+/-)-1-phenyl-3-buten-2-ol;1-Benzylprop-2-en-1-ol;(+/-)-1-phenylbut-3-en-2-ol;4-phenyl-3-hydroxy-1-butene;2-hydroxy-1-phenyl-3-butene;

Chemical Property of alpha-Ethenylbenzeneethanol

Chemical Property:

• Boiling Point: 238℃
• Flash Point: 103℃
• PSA: 20.23000
• Density: 0.999
• LogP: 1.77600

Purity/Quality:

95% ^*data from raw suppliers

1-Phenylbut-3-en-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of alpha-Ethenylbenzeneethanol

There total 44 articles about alpha-Ethenylbenzeneethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

vinyl magnesium bromide (1826-67-1) + phenylacetaldehyde (122-78-1) → 1-phenyl-3-buten-2-ol (6052-66-0,112370-40-8,123877-73-6)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c01166

Reference yield: 93.0%

1-bromo-2,3-epoxy-4-phenylbutane (511553-23-4) → 1-phenyl-3-buten-2-ol (6052-66-0,112370-40-8,123877-73-6)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene;

DOI:10.1021/ja020761x

Reference yield: 88.0%

C26H30OSi (1254120-31-4) → (S)-(+)-1-phenylbut-3-en-2-ol (6052-66-0,123877-73-6,112370-40-8)

Guidance literature:

C₂₆H₃₀OSi; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 17h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; Inert atmosphere;

DOI:10.1021/jo1011202

upstream raw materials:

phenylmagnesium bromide

acrolein

benzylmagnesium chloride

4-Phenylseleno-1-phenylbut-2-en

Downstream raw materials:

(E)-1-[dimethyl(phenyl)silyl]-4-phenylbut-2-ene

3,4-epoxy-1-phenyl-2-butanol

(S)-(+)-1-phenylbut-3-en-2-ol

(2R)-1-phenylbut-3-en-2-ol

Refernces

• 1、 Orfanidou, Maria,Petsi, Marina,Zografos, Alexandros L.. "Organocatalytic epoxidation and allylic oxidation of alkenes by molecular oxygen". supporting information. p. 9172 - 9178. Retrieved 2021/11/30.
• 2、 Jeon, Jinwon,Lee, Changseok,Seo, Huiyeong,Hong, Sungwoo. "NiH-Catalyzed Proximal-Selective Hydroamination of Unactivated Alkenes". supporting information. p. 20470 - 20480. Retrieved 2020/11/27.