[(2R,3S,5R)-5-(6-Benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-sulfamic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:[(2R,3S,5R)-5-(6-Benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-sulfamic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester
CAS No.:142721-40-2
Molecular Formula:C₅₂H₅₃N₁₁O₁₂S
Molecular Weight:1056.13
Hs Code.:

[(2R,3S,5R)-5-(6-Benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-sulfamic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

Synonyms:[(2R,3S,5R)-5-(6-Benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-sulfamic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

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Chemical Property of [(2R,3S,5R)-5-(6-Benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-sulfamic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

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Technology Process of [(2R,3S,5R)-5-(6-Benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-sulfamic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

There total 6 articles about [(2R,3S,5R)-5-(6-Benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-sulfamic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74625-78-8
5'-azido-N⁶-benzoyl-2',5'-dideoxy-adenosine

: 142721-40-2
[(2R,3S,5R)-5-(6-Benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-sulfamic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: t-butyldimethylsilylation

2: H₂ / Pd/C

3: Et₃N, ClSO₂N₃ / acetonitrile

4: 76 percent / Et₃N / CH₂Cl₂

5: Bu₄NF / tetrahydrofuran

With sulfuryl azide chloride; tetrabutyl ammonium fluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo00043a004

Reference yield:

: 139063-19-7
5'-Azido-N₆-benzoyl-3'-O-t-butyldimethylsilyl-2',5'-dideoxyadenosine

: 142721-40-2
[(2R,3S,5R)-5-(6-Benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-sulfamic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C

2: Et₃N, ClSO₂N₃ / acetonitrile

3: 76 percent / Et₃N / CH₂Cl₂

4: Bu₄NF / tetrahydrofuran

With sulfuryl azide chloride; tetrabutyl ammonium fluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo00043a004