N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}cyclopropanecarboxamide

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Chemical Name:N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}cyclopropanecarboxamide
CAS No.:1445889-73-5
Molecular Formula:C₂₃H₂₀ClN₅O
Molecular Weight:417.898
Hs Code.:

Synonyms:N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}cyclopropanecarboxamide

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Chemical Property of N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}cyclopropanecarboxamide

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Technology Process of N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}cyclopropanecarboxamide

There total 10 articles about N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1445891-06-4
N-{4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-N-(2,4-dimethoxybenzyl)cyclopropanecarboxamide

: 1445889-73-5
N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}cyclopropanecarboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 89-98-5
2-chloro-benzaldehyde

: 1445889-73-5
N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride; ammonium chloride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

1.2: 1 h / 20 °C

2.1: sodium t-butanolate / tetrahydrofuran / 3.33 h / -40 - 20 °C

3.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / 1,4-dioxane / 48 h / 20 - 105 °C / Sealed tube

4.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / 0 °C / Inert atmosphere

5.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C

6.1: glyoxal trimer dihydrate; acetic acid / methanol / 32 h / 20 - 45 °C

7.1: caesium carbonate / N,N-dimethyl-formamide / 0.75 h / 20 °C

7.2: 1 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 6 h / 175 °C / Microwave irradiation

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

10.1: trifluoroacetic acid / dichloromethane / 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; lithium aluminium tetrahydride; glyoxal trimer dihydrate; sodium hydride; potassium carbonate; ammonium chloride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; trifluoroacetic acid; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil; butan-1-ol;

Reference yield:

: 1188163-01-0
ethyl 4-(2-chlorophenyl)-1H-pyrrole-3-carboxylate

: 1445889-73-5
N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / 1,4-dioxane / 48 h / 20 - 105 °C / Sealed tube

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / 0 °C / Inert atmosphere

3.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C

4.1: glyoxal trimer dihydrate; acetic acid / methanol / 32 h / 20 - 45 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.75 h / 20 °C

5.2: 1 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 6 h / 175 °C / Microwave irradiation

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; lithium aluminium tetrahydride; glyoxal trimer dihydrate; potassium carbonate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;