N-{4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-N-(2,4-dimethoxybenzyl)cyclopropanecarboxamide

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Chemical Name:N-{4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-N-(2,4-dimethoxybenzyl)cyclopropanecarboxamide
CAS No.:1445891-06-4
Molecular Formula:C₃₈H₄₄ClN₅O₄Si
Molecular Weight:698.337
Hs Code.:

N-{4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-N-(2,4-dimethoxybenzyl)cyclopropanecarboxamide

Synonyms:N-{4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-N-(2,4-dimethoxybenzyl)cyclopropanecarboxamide

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Chemical Property of N-{4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-N-(2,4-dimethoxybenzyl)cyclopropanecarboxamide

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Technology Process of N-{4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-N-(2,4-dimethoxybenzyl)cyclopropanecarboxamide

There total 9 articles about N-{4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-N-(2,4-dimethoxybenzyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1445891-05-3
4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-N-(2,4-dimethoxybenzyl)-5-methylpyridin-2-amine

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1445891-06-4
N-{4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-N-(2,4-dimethoxybenzyl)cyclopropanecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1188163-01-0
ethyl 4-(2-chlorophenyl)-1H-pyrrole-3-carboxylate

: 1445891-06-4
N-{4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-N-(2,4-dimethoxybenzyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / 1,4-dioxane / 48 h / 20 - 105 °C / Sealed tube

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / 0 °C / Inert atmosphere

3.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C

4.1: glyoxal trimer dihydrate; acetic acid / methanol / 32 h / 20 - 45 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.75 h / 20 °C

5.2: 1 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 6 h / 175 °C / Microwave irradiation

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; lithium aluminium tetrahydride; glyoxal trimer dihydrate; potassium carbonate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 24393-51-9
(E)-ethyl 2-chlorocinnamate

: 1445891-06-4
N-{4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-N-(2,4-dimethoxybenzyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium t-butanolate / tetrahydrofuran / 3.33 h / -40 - 20 °C

2.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / 1,4-dioxane / 48 h / 20 - 105 °C / Sealed tube

3.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / 0 °C / Inert atmosphere

4.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C

5.1: glyoxal trimer dihydrate; acetic acid / methanol / 32 h / 20 - 45 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 0.75 h / 20 °C

6.2: 1 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 6 h / 175 °C / Microwave irradiation

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; lithium aluminium tetrahydride; glyoxal trimer dihydrate; potassium carbonate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;