5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(5-methyl-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(5-methyl-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide
CAS No.:1331783-78-8
Molecular Formula:C₂₃H₂₀Cl₃N₅O₂
Molecular Weight:504.803
Hs Code.:

Synonyms:5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(5-methyl-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

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Chemical Property of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(5-methyl-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

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Technology Process of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(5-methyl-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

There total 3 articles about 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(5-methyl-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1332262-52-8
(Z)-N-(1-amino-1-(hydroxyimino)-2-methylpropan-2-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

: 108-24-7
acetic anhydride

: 1331783-78-8
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(5-methyl-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: at 120 ℃; for 4h;
DOI:10.1016/j.bmcl.2011.06.017

Reference yield:

: 1265634-36-3
5-(4-chlorophenyl)-N-(2-cyanopropan-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

: 1331783-78-8
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(5-methyl-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; potassium carbonate / ethanol / 5 h / Reflux

2: 4 h / 120 °C

With hydroxylamine hydrochloride; potassium carbonate; In ethanol;
DOI:10.1016/j.bmcl.2011.06.017

Reference yield:

: 162758-35-2
rimonabant acid

: 1331783-78-8
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(5-methyl-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 10 h / 20 °C

2: hydroxylamine hydrochloride; potassium carbonate / ethanol / 5 h / Reflux

3: 4 h / 120 °C

With hydroxylamine hydrochloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.06.017