5-(4-chlorophenyl)-N-(2-cyanopropan-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

Base Information

• Chemical Name: 5-(4-chlorophenyl)-N-(2-cyanopropan-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
• CAS No.: 1265634-36-3
• Molecular Formula: C₂₁H₁₇Cl₃N₄O
• Molecular Weight: 447.751

Synonyms:5-(4-chlorophenyl)-N-(2-cyanopropan-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

Chemical Property of 5-(4-chlorophenyl)-N-(2-cyanopropan-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

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Technology Process of 5-(4-chlorophenyl)-N-(2-cyanopropan-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

There total 1 articles about 5-(4-chlorophenyl)-N-(2-cyanopropan-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

rimonabant acid (162758-35-2) + 2-amino-2-cyanopropane (19355-69-2) → 5-(4-chlorophenyl)-N-(2-cyanopropan-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (1265634-36-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2010.10.055

Reference yield: 90.0%

5-(4-chlorophenyl)-N-(2-cyanopropan-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (1265634-36-3) → N-(2-(2H-tetrazol-5-yl)propan-2-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (1331784-11-2)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 120 ℃; for 12h;

DOI:10.1016/j.bmcl.2011.06.017

Reference yield: 80.0%

5-(4-chlorophenyl)-N-(2-cyanopropan-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (1265634-36-3) → N-(1-amino-2-methyl-1-thioxopropan-2-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (1331784-01-0)

Guidance literature:

With ammonium hydroxide; hydrogen sulfide; In ethanol; water; at -10 - 20 ℃;

DOI:10.1016/j.bmcl.2011.06.017

upstream raw materials:

rimonabant acid

2-amino-2-cyanopropane

Downstream raw materials:

N-(2-(2H-tetrazol-5-yl)propan-2-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

(Z)-N-(1-amino-1-(hydroxyimino)-2-methylpropan-2-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

4-(bromomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

N-(1-amino-2-methyl-1-thioxopropan-2-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

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