(R)-4-(4-((1-(4-fluorophenyl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzonitrile

Base Information

Chemical Name:(R)-4-(4-((1-(4-fluorophenyl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzonitrile
CAS No.:1350639-78-9
Molecular Formula:C₂₁H₁₆FN₅
Molecular Weight:357.39
Hs Code.:

Synonyms:(R)-4-(4-((1-(4-fluorophenyl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzonitrile

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Chemical Property of (R)-4-(4-((1-(4-fluorophenyl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzonitrile

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Technology Process of (R)-4-(4-((1-(4-fluorophenyl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzonitrile

There total 4 articles about (R)-4-(4-((1-(4-fluorophenyl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 497841-35-7
4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzonitrile

: 374898-01-8
(R)-1-(4-fluorophenyl)ethylamine

: 1350639-78-9
(R)-4-(4-((1-(4-fluorophenyl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzonitrile

Guidance literature:: In butan-1-ol; at 145 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.10.012

Reference yield:

: 497841-34-6
4-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzonitrile

: 1350639-78-9
(R)-4-(4-((1-(4-fluorophenyl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 3 h / 90 °C

1.2: pH 12

2.1: butan-1-ol / 24 h / 145 °C / Inert atmosphere

With trichlorophosphate; In butan-1-ol;
DOI:10.1016/j.ejmech.2011.10.012

Reference yield:

: 497841-33-5
ethyl 2-amino-5-(4-cyanophenyl)-1H-pyrrole-3-carboxylate

: 1350639-78-9
(R)-4-(4-((1-(4-fluorophenyl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: formic acid / N,N-dimethyl-formamide / 20 h / 150 °C

2.1: trichlorophosphate / 3 h / 90 °C

2.2: pH 12

3.1: butan-1-ol / 24 h / 145 °C / Inert atmosphere

With formic acid; trichlorophosphate; In N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1016/j.ejmech.2011.10.012