Strinoline

Base Information

• Chemical Name: Strinoline
• CAS No.: 39862-58-3
• Molecular Formula: C10H6N4
• Molecular Weight: 182.18
• Mol file: 39862-58-3.mol

Synonyms:1,2,4-Triazino[5,6-c]quinoline;<3-14C>-as-Triazino<5,6-c>chinolin;As-triazino<5,6-c>chinolin;

Chemical Property of Strinoline

Chemical Property:

• Vapor Pressure: 1.91E-05mmHg at 25°C
• Melting Point: 161-163 °C
• Boiling Point: 373.6°C at 760 mmHg
• PKA: 1.80±0.10(Predicted)
• Flash Point: 180.1°C
• PSA: 51.56000
• Density: 1.395g/cm³
• LogP: 1.57300

Purity/Quality:

1,2,4-TRIAZINO[5,6-C]QUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Strinoline

There total 7 articles about Strinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-nitro-quinolin-4-ol (50332-66-6) → as-Triazino<5,6-c>chinolin (39862-58-3)

Guidance literature:

Multi-step reaction with 5 steps

1: PCl₅, POCl₃ / Heating

2: N₂H₄*H₂O / propan-2-ol / 20 h / Ambient temperature

3: H₂ / 5percent Pd/C / aq. ethanol

4: conc. HCl / 2.5 h

5: MnO₂, 5 M NaOH / H₂O / 0.83 h / pH 6

With hydrogenchloride; manganese(IV) oxide; sodium hydroxide; phosphorus pentachloride; hydrogen; hydrazine hydrate; trichlorophosphate; palladium on activated charcoal; In ethanol; water; isopropyl alcohol;

DOI:10.1021/jm00131a010

Reference yield:

4-chloro-3-nitroquinoline (39061-97-7) → as-Triazino<5,6-c>chinolin (39862-58-3)

Guidance literature:

Multi-step reaction with 4 steps

1: N₂H₄*H₂O / propan-2-ol / 20 h / Ambient temperature

2: H₂ / 5percent Pd/C / aq. ethanol

3: conc. HCl / 2.5 h

4: MnO₂, 5 M NaOH / H₂O / 0.83 h / pH 6

With hydrogenchloride; manganese(IV) oxide; sodium hydroxide; hydrogen; hydrazine hydrate; palladium on activated charcoal; In ethanol; water; isopropyl alcohol;

DOI:10.1021/jm00131a010

Reference yield:

2-<2-nitroethylideneamino>benzoic acid (121845-92-9) → as-Triazino<5,6-c>chinolin (39862-58-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) Ac₂O, 2.) NaOAc / 1.) reflux, 1 h, 2.) a) 100 deg C, b) 25 deg C, overnight

2: PCl₅, POCl₃ / Heating

3: N₂H₄*H₂O / propan-2-ol / 20 h / Ambient temperature

4: H₂ / 5percent Pd/C / aq. ethanol

5: conc. HCl / 2.5 h

6: MnO₂, 5 M NaOH / H₂O / 0.83 h / pH 6

With hydrogenchloride; manganese(IV) oxide; sodium hydroxide; phosphorus pentachloride; hydrogen; sodium acetate; acetic anhydride; hydrazine hydrate; trichlorophosphate; palladium on activated charcoal; In ethanol; water; isopropyl alcohol;

DOI:10.1021/jm00131a010

upstream raw materials:

1,2-Dihydro-as-triazino<5,6-c>-chinolin-Hydrochlorid

3-nitro-quinolin-4-ol

4-chloro-3-nitroquinoline

2-<2-nitroethylideneamino>benzoic acid

Refernces

• 1、 Berenyi,Benko,Pallos. "Condensed as-triazines. IV. Synthesis of as-triazino[5,6-c]quinoline and its derivatives". . p. 399 - 404. Retrieved 2007/10/05.