121845-92-9

Basic information

• Product Name: Benzoic acid, 2-[(2-nitroethylidene)amino]- (9CI)
• Synonyms: Benzoic acid, 2-[(2-nitroethylidene)amino]- (9CI);2-(2-Nitro-ethylideneamino)-benzoic Acid;N-(2-Nitro-ethyliden)-anthranilic Aci;N-(2-Nitro-ethyliden)-anthranilic Acid;(E)-2-((2-nitroethylidene)amino)benzoic acid
• CAS NO: 121845-92-9
• Molecular Formula: C₉H₈N₂O₄
• Molecular Weight: 208.17082
• Product Categories: AMINOACID;Aromatics Compounds;Aromatics
• Mol File: 121845-92-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 1970C
• Appearance: /
• Solubility: Acetone, Methanol
• Stability: <-200C
• CAS DataBase Reference: Benzoic acid, 2-[(2-nitroethylidene)amino]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-[(2-nitroethylidene)amino]- (9CI)(121845-92-9)
• EPA Substance Registry System: Benzoic acid, 2-[(2-nitroethylidene)amino]- (9CI)(121845-92-9)

Safety Data

• Hazardous Substances Data: 121845-92-9(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

2-(2-Nitro-ethylideneamino)benzoic Acid (cas# 121845-92-9) is a compound useful in organic synthesis.

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 365, 1947 DOI: 10.1021/ja01194a060

Upstream product

• 5653-21-4 metazonic acid 
• 118-92-3 anthranilic acid 
• 56813-76-4 1,1-dichloro-2-nitroethane 
• 552-37-4 sodium o-aminobenzoate 
• 75-52-5 nitromethane 
• 99584-53-9 1,1-dibromo-2-nitro-ethane 
• 2099-63-0 anthranilic acid hydrochloride 

Downstream Products

• 42606-33-7 3-nitro-4-aminoquinoline 
• 39061-97-7 4-chloro-3-nitroquinoline 
• 132206-92-9 4-chloro-1H-imidazo[4,5-c]-quinoline 
• 132206-99-6 N-phenyl-2-cyclopentyl-1H-imidazo[4,5-c]quinolin-4-amine 
• 1421771-49-4 C₂₀H₁₇N₃OS 
• 1421771-62-1 C₂₀H₁₉N₃O₂S₂ 
• 103862-98-2 N-(4-hydroxyquinolin-3-yl)acetamide 
• 256922-53-9 2-propyl[1,3]thiazolo[4,5-c]quinolin-4-amine 
• 129655-57-8 2-methyl-1-(3-nitroquinolin-4-ylamino)propan-2-ol 
• 129655-59-0 1-[(3-amino-4-quinolinyl)amino]-2-methyl-2-propanol 
• 58401-43-7 3-amino-4-chloroquinoleine 
• 99512-72-8 3-amino-4-hydroxyquinoline 

Relevant articles and documents

Regioisomerism-dependent TLR7 agonism and antagonism in an imidazoquinoline

Chronic immune activation is a hallmark of progressive HIV infection. Recent reports point to the engagement of toll-like receptor 7 (TLR7) and -9 by viral RNA as contributing to the activation of innate immune responses, which drive viral replication leading to immune exhaustion. The only known class of TLR7 antagonists is single-stranded phosphorothioate oligonucleotides, which has been demonstrated to inhibit immune activation in human and Rhesus macaque in vitro models. The availability of a selective and potent small-molecule TLR7 antagonist should allow the evaluation of potential benefits of suppression of TLR7-mediated immune activation in HIV/AIDS. Gardiquimod is a known N1-substituted 1H-imidazoquinoline TLR7 agonist, the synthesis of which has not been published. We show that the 3H regioisomer is completely inactive as a TLR7 agonist and is weakly antagonistic. A des-amino precursor of the 3H regioisomer is more potent as a TLR7 antagonist, with an IC50 value of 7.5 μM. This class of compound may serve as a starting point for the development of small-molecule inhibitors of TLR7.

LOCALLY ACTING TOLL-LIKE RECEPTOR 7 (TLR7) AND/OR TLR8 AGONIST IMMUNOTHERAPY COMPOUNDS AND THEIR USES

Provided in the present disclosure are immunotherapy compounds, pharmaceutical compositions thereof and their use, wherein the immunotherapy compounds, upon local administration, form depots inducing cell mediated immune response while mitigating a systemic proinflammatory immune response.

A3 ADENOSINE RECEPTOR ALLOSTERIC MODULATORS

The present invention relates to allosteric modulation of A3 adenosine receptor (A3AR) and provides for the use of an A3 adenosine receptor modulator (A3RM),for the preparation of pharmaceutical compositions for