(1'S,6R)-1-(benzyloxycarbonyl)-3-(1'-phenyleth-1'-yl)-6-phenylperihydropyrimidin-4-one

Base Information

Chemical Name:(1'S,6R)-1-(benzyloxycarbonyl)-3-(1'-phenyleth-1'-yl)-6-phenylperihydropyrimidin-4-one
CAS No.:138261-27-5
Molecular Formula:C₂₆H₂₆N₂O₃
Molecular Weight:414.504
Hs Code.:

Synonyms:(1'S,6R)-1-(benzyloxycarbonyl)-3-(1'-phenyleth-1'-yl)-6-phenylperihydropyrimidin-4-one

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Chemical Property of (1'S,6R)-1-(benzyloxycarbonyl)-3-(1'-phenyleth-1'-yl)-6-phenylperihydropyrimidin-4-one

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Technology Process of (1'S,6R)-1-(benzyloxycarbonyl)-3-(1'-phenyleth-1'-yl)-6-phenylperihydropyrimidin-4-one

There total 11 articles about (1'S,6R)-1-(benzyloxycarbonyl)-3-(1'-phenyleth-1'-yl)-6-phenylperihydropyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140-10-3
(E)-3-phenylacrylic acid

: 138261-27-5
(1'S,6R)-1-(benzyloxycarbonyl)-3-(1'-phenyleth-1'-yl)-6-phenylperihydropyrimidin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: NH₂OH*HCl, EtONa / aq. ethanol / 9 h / Heating

2: aq. NaOH / acetone / 1 h / Ambient temperature

3: SOCl₂ / CH₂Cl₂ / 0.5 h / Ambient temperature

4: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

5: p-TsOH*H₂O / benzene / 1 h / Heating

With sodium hydroxide; thionyl chloride; hydroxylamine hydrochloride; sodium ethanolate; toluene-4-sulfonic acid; triethylamine; In ethanol; dichloromethane; acetone; benzene;
DOI:10.1021/jo00103a020

Reference yield:

: 3646-50-2
3-Amino-3-phenylpropionic acid

: 138261-27-5
(1'S,6R)-1-(benzyloxycarbonyl)-3-(1'-phenyleth-1'-yl)-6-phenylperihydropyrimidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / acetone / 1 h / Ambient temperature

2: SOCl₂ / CH₂Cl₂ / 0.5 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: p-TsOH*H₂O / benzene / 1 h / Heating

With sodium hydroxide; thionyl chloride; toluene-4-sulfonic acid; triethylamine; In dichloromethane; acetone; benzene;
DOI:10.1021/jo00103a020

Reference yield:

: 14440-98-3
N-(benzyloxycarbonyl)-DL-3-amino-3-phenylpropionic acid

: 138261-27-5
(1'S,6R)-1-(benzyloxycarbonyl)-3-(1'-phenyleth-1'-yl)-6-phenylperihydropyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CH₂Cl₂ / 0.5 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

3: p-TsOH*H₂O / benzene / 1 h / Heating

With thionyl chloride; toluene-4-sulfonic acid; triethylamine; In dichloromethane; benzene;
DOI:10.1021/jo00103a020