(4bS,7R,8aS)-4b-(3-Benzyloxy-propyl)-7-methyl-4b,6,7,8,8a,9-hexahydro-indeno[2,1-b]pyridin-5-one

Base Information

Chemical Name:(4bS,7R,8aS)-4b-(3-Benzyloxy-propyl)-7-methyl-4b,6,7,8,8a,9-hexahydro-indeno[2,1-b]pyridin-5-one
CAS No.:915122-91-7
Molecular Formula:C₂₃H₂₇NO₂
Molecular Weight:349.473
Hs Code.:

Synonyms:(4bS,7R,8aS)-4b-(3-Benzyloxy-propyl)-7-methyl-4b,6,7,8,8a,9-hexahydro-indeno[2,1-b]pyridin-5-one

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Chemical Property of (4bS,7R,8aS)-4b-(3-Benzyloxy-propyl)-7-methyl-4b,6,7,8,8a,9-hexahydro-indeno[2,1-b]pyridin-5-one

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Technology Process of (4bS,7R,8aS)-4b-(3-Benzyloxy-propyl)-7-methyl-4b,6,7,8,8a,9-hexahydro-indeno[2,1-b]pyridin-5-one

There total 14 articles about (4bS,7R,8aS)-4b-(3-Benzyloxy-propyl)-7-methyl-4b,6,7,8,8a,9-hexahydro-indeno[2,1-b]pyridin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: C₂₁H₂₆O₃

: (N-vinylimino)phosphorene

: 915122-91-7
(4bS,7R,8aS)-4b-(3-Benzyloxy-propyl)-7-methyl-4b,6,7,8,8a,9-hexahydro-indeno[2,1-b]pyridin-5-one

Guidance literature:: In benzene; at 90 ℃; for 2h; Sealed tube;
DOI:10.1039/c8cc01626g

Reference yield: 60.0%

: 915122-90-6
(3aS,6R,7aS)-3a-(3-Benzyloxy-propyl)-3-[(E)-3-(dimethyl-hydrazono)-propenyl]-6-methyl-1,3a,5,6,7,7a-hexahydro-inden-4-one

: 915122-91-7
(4bS,7R,8aS)-4b-(3-Benzyloxy-propyl)-7-methyl-4b,6,7,8,8a,9-hexahydro-indeno[2,1-b]pyridin-5-one

Guidance literature:: In toluene; at 190 ℃; for 4h;
DOI:10.1002/anie.200602035

Reference yield:

: 915122-87-1
(R)-2-(3-Benzyloxy-propyl)-5-methyl-cyclohex-2-enone

: 915122-91-7
(4bS,7R,8aS)-4b-(3-Benzyloxy-propyl)-7-methyl-4b,6,7,8,8a,9-hexahydro-indeno[2,1-b]pyridin-5-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: CH₂Cl₂ / 0.17 h / -78 °C

1.2: CH₂Cl₂ / -78 - -10 °C

2.1: 82 percent / N-iodosuccinimide; AgNO₃ / dimethylformamide / 2 h / 0 - 20 °C

3.1: 95 percent / Ph₃PAuBF₄ / CH₂Cl₂; methanol / 3 h / 40 °C

4.1: 83 percent / NaOMe / Pd(PPh₃)4 / methanol; benzene / 2 h / 80 °C

5.1: 60 percent / toluene / 4 h / 190 °C

With N-iodo-succinimide; (triphenylphosphine)gold(I) tetrafluoroborate; sodium methylate; silver nitrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; benzene; 4.1: Suzuki coupling;
DOI:10.1002/anie.200602035