(3aS,6R,7aS)-3a-(3-Benzyloxy-propyl)-3-[(E)-3-(dimethyl-hydrazono)-propenyl]-6-methyl-1,3a,5,6,7,7a-hexahydro-inden-4-one

Base Information

Chemical Name:(3aS,6R,7aS)-3a-(3-Benzyloxy-propyl)-3-[(E)-3-(dimethyl-hydrazono)-propenyl]-6-methyl-1,3a,5,6,7,7a-hexahydro-inden-4-one
CAS No.:915122-90-6
Molecular Formula:C₂₅H₃₄N₂O₂
Molecular Weight:394.557
Hs Code.:

Synonyms:(3aS,6R,7aS)-3a-(3-Benzyloxy-propyl)-3-[(E)-3-(dimethyl-hydrazono)-propenyl]-6-methyl-1,3a,5,6,7,7a-hexahydro-inden-4-one

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Chemical Property of (3aS,6R,7aS)-3a-(3-Benzyloxy-propyl)-3-[(E)-3-(dimethyl-hydrazono)-propenyl]-6-methyl-1,3a,5,6,7,7a-hexahydro-inden-4-one

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Technology Process of (3aS,6R,7aS)-3a-(3-Benzyloxy-propyl)-3-[(E)-3-(dimethyl-hydrazono)-propenyl]-6-methyl-1,3a,5,6,7,7a-hexahydro-inden-4-one

There total 6 articles about (3aS,6R,7aS)-3a-(3-Benzyloxy-propyl)-3-[(E)-3-(dimethyl-hydrazono)-propenyl]-6-methyl-1,3a,5,6,7,7a-hexahydro-inden-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 915122-89-3
(3aR,6R,7aS)-3a-(3-Benzyloxy-propyl)-3-iodo-6-methyl-1,3a,5,6,7,7a-hexahydro-inden-4-one

: 314045-12-0
N,N-dimethyl-N'-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-allylidene]-hydrazine

: 915122-90-6
(3aS,6R,7aS)-3a-(3-Benzyloxy-propyl)-3-[(E)-3-(dimethyl-hydrazono)-propenyl]-6-methyl-1,3a,5,6,7,7a-hexahydro-inden-4-one

Guidance literature:: With sodium methylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; benzene; at 80 ℃; for 2h;
DOI:10.1002/anie.200602035

Reference yield:

: 915122-87-1
(R)-2-(3-Benzyloxy-propyl)-5-methyl-cyclohex-2-enone

: 915122-90-6
(3aS,6R,7aS)-3a-(3-Benzyloxy-propyl)-3-[(E)-3-(dimethyl-hydrazono)-propenyl]-6-methyl-1,3a,5,6,7,7a-hexahydro-inden-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: CH₂Cl₂ / 0.17 h / -78 °C

1.2: CH₂Cl₂ / -78 - -10 °C

2.1: 82 percent / N-iodosuccinimide; AgNO₃ / dimethylformamide / 2 h / 0 - 20 °C

3.1: 95 percent / Ph₃PAuBF₄ / CH₂Cl₂; methanol / 3 h / 40 °C

4.1: 83 percent / NaOMe / Pd(PPh₃)4 / methanol; benzene / 2 h / 80 °C

With N-iodo-succinimide; (triphenylphosphine)gold(I) tetrafluoroborate; sodium methylate; silver nitrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene; 4.1: Suzuki coupling;
DOI:10.1002/anie.200602035

Reference yield:

: 915122-92-8
(R)-5-methyl-2-iodo-2-cyclohexen-1-one

: 915122-90-6
(3aS,6R,7aS)-3a-(3-Benzyloxy-propyl)-3-[(E)-3-(dimethyl-hydrazono)-propenyl]-6-methyl-1,3a,5,6,7,7a-hexahydro-inden-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: BH₃*THF / tetrahydrofuran / 8 h / 20 °C

1.2: 72 percent / Cs₂CO₃; Ph₃As / Pd(dppf)Cl₂ / tetrahydrofuran; H₂O / 2 h / 20 - 50 °C

2.1: CH₂Cl₂ / 0.17 h / -78 °C

2.2: CH₂Cl₂ / -78 - -10 °C

3.1: 82 percent / N-iodosuccinimide; AgNO₃ / dimethylformamide / 2 h / 0 - 20 °C

4.1: 95 percent / Ph₃PAuBF₄ / CH₂Cl₂; methanol / 3 h / 40 °C

5.1: 83 percent / NaOMe / Pd(PPh₃)4 / methanol; benzene / 2 h / 80 °C

With N-iodo-succinimide; borane-THF; (triphenylphosphine)gold(I) tetrafluoroborate; sodium methylate; silver nitrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene; 1.2: Suzuki-Miyaura coupling / 5.1: Suzuki coupling;
DOI:10.1002/anie.200602035