cyclopentyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate

Base Information

Chemical Name:cyclopentyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate
CAS No.:1445786-46-8
Molecular Formula:C₂₈H₂₇N₅O₆
Molecular Weight:529.552
Hs Code.:

Synonyms:cyclopentyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate

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Chemical Property of cyclopentyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate

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Technology Process of cyclopentyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate

There total 4 articles about cyclopentyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 137-43-9
Cyclopentyl bromide

: 1445788-80-6
3-({3-carbamoyl-7-[2,4-bis(methyloxy)-5-pyrimidinyl]-4-quinolinyl}amino)-5-hydroxybenzoic acid

: 1445786-46-8
cyclopentyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 1374867-81-8
7-bromo-4-chloroquinoline-3-carboxamide

: 1445786-46-8
cyclopentyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 75 °C

2: acetic acid / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 150 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 860205-92-1,154326-11-1
7-bromo-4-hydroxy-3-quinolinecarboxylic acid

: 1445786-46-8
cyclopentyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / Reflux

1.2: 2 h / Cooling with ice

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 75 °C

3.1: acetic acid / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 150 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; trichlorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide;