3-({3-carbamoyl-7-[2,4-bis(methyloxy)-5-pyrimidinyl]-4-quinolinyl}amino)-5-hydroxybenzoic acid

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Chemical Name:3-({3-carbamoyl-7-[2,4-bis(methyloxy)-5-pyrimidinyl]-4-quinolinyl}amino)-5-hydroxybenzoic acid
CAS No.:1445788-80-6
Molecular Formula:C₂₃H₁₉N₅O₆
Molecular Weight:461.434
Hs Code.:

Synonyms:3-({3-carbamoyl-7-[2,4-bis(methyloxy)-5-pyrimidinyl]-4-quinolinyl}amino)-5-hydroxybenzoic acid

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Chemical Property of 3-({3-carbamoyl-7-[2,4-bis(methyloxy)-5-pyrimidinyl]-4-quinolinyl}amino)-5-hydroxybenzoic acid

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Technology Process of 3-({3-carbamoyl-7-[2,4-bis(methyloxy)-5-pyrimidinyl]-4-quinolinyl}amino)-5-hydroxybenzoic acid

There total 3 articles about 3-({3-carbamoyl-7-[2,4-bis(methyloxy)-5-pyrimidinyl]-4-quinolinyl}amino)-5-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1374867-83-0
4-chloro-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide

: 76045-71-1
3-amino-5-hydroxybenzoic acid

: 1445788-80-6
3-({3-carbamoyl-7-[2,4-bis(methyloxy)-5-pyrimidinyl]-4-quinolinyl}amino)-5-hydroxybenzoic acid

Guidance literature:: With acetic acid; at 20 ℃;

Reference yield:

: 1374867-81-8
7-bromo-4-chloroquinoline-3-carboxamide

: 1445788-80-6
3-({3-carbamoyl-7-[2,4-bis(methyloxy)-5-pyrimidinyl]-4-quinolinyl}amino)-5-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 75 °C

2: acetic acid / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; In 1,4-dioxane; water;

Reference yield:

: 860205-92-1,154326-11-1
7-bromo-4-hydroxy-3-quinolinecarboxylic acid

: 1445788-80-6
3-({3-carbamoyl-7-[2,4-bis(methyloxy)-5-pyrimidinyl]-4-quinolinyl}amino)-5-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / Reflux

1.2: 2 h / Cooling with ice

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 75 °C

3.1: acetic acid / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; trichlorophosphate; In 1,4-dioxane; water;