2-(R)-2-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-pentanedioic acid, 1-tert-butyl-5-benzyl ester

Base Information

Chemical Name:2-(R)-2-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-pentanedioic acid, 1-tert-butyl-5-benzyl ester
CAS No.:817562-89-3
Molecular Formula:C₄₂H₇₀N₄O₁₀
Molecular Weight:791.039
Hs Code.:

Synonyms:2-(R)-2-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-pentanedioic acid, 1-tert-butyl-5-benzyl ester

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Chemical Property of 2-(R)-2-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-pentanedioic acid, 1-tert-butyl-5-benzyl ester

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Technology Process of 2-(R)-2-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-pentanedioic acid, 1-tert-butyl-5-benzyl ester

There total 5 articles about 2-(R)-2-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-pentanedioic acid, 1-tert-butyl-5-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 817562-88-2
2-(R)-2-(1,4,7,10-tetraazacyclododec-1-yl)pentanedioic acid, 1-tert-butyl-5-benzyl ester

: 5292-43-3
bromoacetic acid tert-butyl ester

: 817562-89-3
2-(R)-2-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-pentanedioic acid, 1-tert-butyl-5-benzyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; for 1h;

Reference yield:

: 817562-87-1
2-(S)-2-(methylsulfonyloxy)pentanedioic acid, 1-tert-butyl-5-benzyl ester

: 5292-43-3
bromoacetic acid tert-butyl ester

: 294-90-6
1,4,7,10-tetraazacyclododecan

: 817562-89-3
2-(R)-2-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-pentanedioic acid, 1-tert-butyl-5-benzyl ester

Guidance literature:: bromoacetic acid tert-butyl ester; 1,4,7,10-tetraazacyclododecan; With sodium acetate; at 0 - 20 ℃; for 16h;

2-(S)-2-(methylsulfonyloxy)pentanedioic acid, 1-tert-butyl-5-benzyl ester; With potassium carbonate; In acetonitrile; at 20 - 60 ℃; for 16h;
DOI:10.1039/c5ra20359g

Reference yield:

: 817562-86-0
2-(S)-2-hydroxypentanedioic acid, 1-tert-butyl-5-benzyl ester

: 817562-89-3
2-(R)-2-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-pentanedioic acid, 1-tert-butyl-5-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 20 °C

2.1: sodium acetate / 16 h / 0 - 20 °C

2.2: 16 h / 20 - 60 °C

With sodium acetate; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1039/c5ra20359g