5'-O-(4,4'-dimethoxytrityl)-(O₃'->S₅')dithymidine-O-(2-cyanoethyl)phosphorodithioate

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-(O₃'->S₅')dithymidine-O-(2-cyanoethyl)phosphorodithioate
• CAS No.: 1164117-96-7
• Molecular Formula: C₄₄H₄₈N₅O₁₂PS₂
• Molecular Weight: 933.997

Synonyms:5'-O-(4,4'-dimethoxytrityl)-(O₃'->S₅')dithymidine-O-(2-cyanoethyl)phosphorodithioate

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-(O₃'->S₅')dithymidine-O-(2-cyanoethyl)phosphorodithioate

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-(O₃'->S₅')dithymidine-O-(2-cyanoethyl)phosphorodithioate

There total 1 articles about 5'-O-(4,4'-dimethoxytrityl)-(O₃'->S₅')dithymidine-O-(2-cyanoethyl)phosphorodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-((2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (25953-14-4,94892-66-7) + O-<5'-O-(4,4'-dimethoxytrityl)-thymidin-3'-yl> O-(β-cyanoethyl) phosphorodithioate triethylammonium salt → 5'-O-(4,4'-dimethoxytrityl)-(O3'->S5')dithymidine-O-(2-cyanoethyl)phosphorodithioate (1164117-96-7)

Guidance literature:

With N,N-dimethyl-formamide; In acetonitrile; at 50 ℃; for 36h;

DOI:10.1039/b901791g

Reference yield:

5'-O-(4,4'-dimethoxytrityl)-(O3'->S5')dithymidine-O-(2-cyanoethyl)phosphorodithioate (1164117-96-7) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → C53H65N7O13P2S2

Guidance literature:

With 5-(ethylthio)-1H-tetrazole; In acetonitrile; at 20 ℃; for 1.25h;

DOI:10.1039/b901791g

upstream raw materials:

1-((2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

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