1-[7-Fluoro-4-(4-fluoro-phenyl)-3,4-dihydro-1H-pyrrolo[3,4-b]indol-2-yl]-propan-1-one

Base Information

Chemical Name:1-[7-Fluoro-4-(4-fluoro-phenyl)-3,4-dihydro-1H-pyrrolo[3,4-b]indol-2-yl]-propan-1-one
CAS No.:343836-01-1
Molecular Formula:C₁₉H₁₆F₂N₂O
Molecular Weight:326.346
Hs Code.:

Synonyms:1-[7-Fluoro-4-(4-fluoro-phenyl)-3,4-dihydro-1H-pyrrolo[3,4-b]indol-2-yl]-propan-1-one

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Chemical Property of 1-[7-Fluoro-4-(4-fluoro-phenyl)-3,4-dihydro-1H-pyrrolo[3,4-b]indol-2-yl]-propan-1-one

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Technology Process of 1-[7-Fluoro-4-(4-fluoro-phenyl)-3,4-dihydro-1H-pyrrolo[3,4-b]indol-2-yl]-propan-1-one

There total 3 articles about 1-[7-Fluoro-4-(4-fluoro-phenyl)-3,4-dihydro-1H-pyrrolo[3,4-b]indol-2-yl]-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 343836-01-1
1-[7-Fluoro-4-(4-fluoro-phenyl)-3,4-dihydro-1H-pyrrolo[3,4-b]indol-2-yl]-propan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium acetate, 2.) 85percent H₃PO₄ / 1.) water, 20 min, 2.) RT, 1 h

2: 60 percent / Cu₂Br₂, Na₂CO₃, N-methylpyrrolidinone / 4 h / Heating

3: KOH / ethanol; H₂O / 18 h / Heating

4: Et₃N / CH₂Cl₂

With 1-methyl-pyrrolidin-2-one; copper(I) bromide; potassium hydroxide; phosphoric acid; sodium acetate; sodium carbonate; triethylamine; In ethanol; dichloromethane; water;
DOI:10.1021/jm00180a030

Reference yield:

: 58039-19-3
7-fluoro-4-(p-fluorophenyl)-2-carbethoxy-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

: 343836-01-1
1-[7-Fluoro-4-(4-fluoro-phenyl)-3,4-dihydro-1H-pyrrolo[3,4-b]indol-2-yl]-propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / ethanol; H₂O / 18 h / Heating

2: Et₃N / CH₂Cl₂

With potassium hydroxide; triethylamine; In ethanol; dichloromethane; water;
DOI:10.1021/jm00180a030

Reference yield:

: 58039-18-2
7-fluoro-2-carbethoxy-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

: 343836-01-1
1-[7-Fluoro-4-(4-fluoro-phenyl)-3,4-dihydro-1H-pyrrolo[3,4-b]indol-2-yl]-propan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / Cu₂Br₂, Na₂CO₃, N-methylpyrrolidinone / 4 h / Heating

2: KOH / ethanol; H₂O / 18 h / Heating

3: Et₃N / CH₂Cl₂

With 1-methyl-pyrrolidin-2-one; copper(I) bromide; potassium hydroxide; sodium carbonate; triethylamine; In ethanol; dichloromethane; water;
DOI:10.1021/jm00180a030