(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-difluorophenyl)-2-(4-methyl-1-piperazinyl)acetohydrazide

Base Information

Chemical Name:(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-difluorophenyl)-2-(4-methyl-1-piperazinyl)acetohydrazide
CAS No.:1092477-50-3
Molecular Formula:C₂₁H₂₀F₈N₄O
Molecular Weight:496.403
Hs Code.:

Synonyms:(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-difluorophenyl)-2-(4-methyl-1-piperazinyl)acetohydrazide

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Chemical Property of (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-difluorophenyl)-2-(4-methyl-1-piperazinyl)acetohydrazide

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Technology Process of (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-difluorophenyl)-2-(4-methyl-1-piperazinyl)acetohydrazide

There total 4 articles about (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-difluorophenyl)-2-(4-methyl-1-piperazinyl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 886-35-1
3,5-bis(trifluoromethyl)phenylhydrazine

: 1092477-49-0
(+/-)-(2,3-difluorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride

: 1092477-50-3
(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-difluorophenyl)-2-(4-methyl-1-piperazinyl)acetohydrazide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1092477-50-3
(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-difluorophenyl)-2-(4-methyl-1-piperazinyl)acetohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile;

Reference yield:

: 1092477-48-9
(+/-)-bromo(2,3-difluorophenyl)acetic acid

: 1092477-50-3
(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-difluorophenyl)-2-(4-methyl-1-piperazinyl)acetohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile;