(+/-)-(2,3-difluorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride

Base Information

• Chemical Name: (+/-)-(2,3-difluorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride
• CAS No.: 1092477-49-0
• Molecular Formula: C₁₃H₁₆F₂N₂O₂*ClH
• Molecular Weight: 306.74
• Mol file: 1092477-49-0.mol

Synonyms:(+/-)-(2,3-difluorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride

Chemical Property of (+/-)-(2,3-difluorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-(2,3-difluorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride

There total 2 articles about (+/-)-(2,3-difluorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

1-methyl-piperazine (109-01-3) + (+/-)-bromo(2,3-difluorophenyl)acetic acid (1092477-48-9) → (+/-)-(2,3-difluorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride (1092477-49-0)

Guidance literature:

1-methyl-piperazine; (+/-)-bromo(2,3-difluorophenyl)acetic acid; With potassium carbonate; In acetonitrile; at 20 ℃;

With hydrogenchloride; water;

Reference yield:

2-(2,3-difluorophenyl)acetic acid (145689-41-4) → (+/-)-(2,3-difluorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride (1092477-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 5 h / 80 °C

2: potassium carbonate / acetonitrile / 20 °C

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In tetrachloromethane; acetonitrile;

Reference yield: 35.0%

3,5-bis(trifluoromethyl)phenylhydrazine (886-35-1) + (+/-)-(2,3-difluorophenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride (1092477-49-0) → (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-difluorophenyl)-2-(4-methyl-1-piperazinyl)acetohydrazide (1092477-50-3)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

1-methyl-piperazine

(+/-)-bromo(2,3-difluorophenyl)acetic acid

2-(2,3-difluorophenyl)acetic acid

Downstream raw materials:

(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-difluorophenyl)-2-(4-methyl-1-piperazinyl)acetohydrazide

(R)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-difluorophenyl)-2-(4-methyl-1-piperazinyl)acetohydrazide

(S)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,3-difluorophenyl)-2-(4-methyl-1-piperazinyl)acetohydrazide