9-Methoxy-11-phenyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one

Base Information

• Chemical Name: 9-Methoxy-11-phenyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one
• CAS No.: 127300-33-8
• Molecular Formula: C₁₉H₁₈N₂O₂
• Molecular Weight: 306.364

Synonyms:9-Methoxy-11-phenyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one

Chemical Property of 9-Methoxy-11-phenyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one

Chemical Property:

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Technology Process of 9-Methoxy-11-phenyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one

There total 2 articles about 9-Methoxy-11-phenyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-(3-Amino-propyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester (127300-24-7) → 9-Methoxy-11-phenyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one (127300-33-8)

Guidance literature:

With sodium hydride; In xylene; for 6h; Heating;

DOI:10.1002/jps.2600790218

Reference yield:

1-(2-Cyano-ethyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester (127300-19-0) → 9-Methoxy-11-phenyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one (127300-33-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Raney-Ni / methanol / 6 h / 3111.2 Torr

2: 72 percent / NaH / xylene / 6 h / Heating

With hydrogen; sodium hydride; nickel; In methanol; xylene;

DOI:10.1002/jps.2600790218

Reference yield: 59.0%

9-Methoxy-11-phenyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one (127300-33-8) → 9-Methoxy-11-phenyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole (127300-38-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 12h; Heating;

DOI:10.1002/jps.2600790218

upstream raw materials:

1-(3-Amino-propyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester

1-(2-Cyano-ethyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester

Downstream raw materials:

9-Methoxy-11-phenyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole

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