1-(2-Cyano-ethyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-(2-Cyano-ethyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester
• CAS No.: 127300-19-0
• Molecular Formula: C₂₁H₂₀N₂O₃
• Molecular Weight: 348.401

Synonyms:1-(2-Cyano-ethyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester

Chemical Property of 1-(2-Cyano-ethyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 1-(2-Cyano-ethyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester

There total 1 articles about 1-(2-Cyano-ethyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 5-methoxy-3-phenyl-1H-indole-2-carboxylate (27294-08-2) + acrylonitrile (107-13-1,25014-41-9) → 1-(2-Cyano-ethyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester (127300-19-0)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; In 1,4-dioxane; at 80 ℃; for 2h;

DOI:10.1002/jps.2600790218

Reference yield: 65.0%

1-(2-Cyano-ethyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester (127300-19-0) → [1-(3-Amino-propyl)-5-methoxy-3-phenyl-1H-indol-2-yl]-methanol (127300-42-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 10h; Heating;

DOI:10.1002/jps.2600790218

Reference yield:

1-(2-Cyano-ethyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester (127300-19-0) → 1-(3-Amino-propyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester (127300-24-7)

Guidance literature:

With hydrogen; nickel; In methanol; for 6h; under 3111.2 Torr;

DOI:10.1002/jps.2600790218

upstream raw materials:

ethyl 5-methoxy-3-phenyl-1H-indole-2-carboxylate

acrylonitrile

Downstream raw materials:

[1-(3-Amino-propyl)-5-methoxy-3-phenyl-1H-indol-2-yl]-methanol

1-(3-Amino-propyl)-5-methoxy-3-phenyl-1H-indole-2-carboxylic acid ethyl ester

9-Methoxy-11-phenyl-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one

9-Methoxy-11-phenyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole

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