(S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-benzylurea

Base Information

Chemical Name:(S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-benzylurea
CAS No.:1417654-25-1
Molecular Formula:C₂₃H₂₃I₂N₃O₃
Molecular Weight:643.263
Hs Code.:

Synonyms:(S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-benzylurea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-benzylurea

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Technology Process of (S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-benzylurea

There total 6 articles about (S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-benzylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1417654-04-6
(S)-tert-butyl (1-amino-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

: 3173-56-6
benzyl isothiocyanate

: 1417654-25-1
(S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-benzylurea

Guidance literature:: (S)-tert-butyl (1-amino-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate; benzyl isothiocyanate; In tetrahydrofuran; at 20 ℃; for 0.5h;

With triethylsilane; trifluoroacetic acid; In dichloromethane; for 0.25h;

Reference yield:

: 1417654-01-3
(S)-tert-butyl (1-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)-3-hydroxypropan-2-yl)carbamate

: 1417654-25-1
(S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-benzylurea

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide / toluene / 4.5 h / 20 °C / Cooling with ice

2.1: sodium azide / N,N-dimethyl-formamide / 24 h / 80 °C

3.1: triphenylphosphine / tetrahydrofuran; water / 18 h / 20 °C

4.1: tetrahydrofuran / 0.5 h / 20 °C

4.2: 0.25 h

With sodium azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1417654-00-2
(S)-tert-butyl (1-hydroxy-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propan-2-yl)carbamate

: 1417654-25-1
(S)-1-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)-3-benzylurea

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide / toluene / 4.5 h / 20 °C / Cooling with ice

3.1: sodium azide / N,N-dimethyl-formamide / 24 h / 80 °C

4.1: triphenylphosphine / tetrahydrofuran; water / 18 h / 20 °C

5.1: tetrahydrofuran / 0.5 h / 20 °C

5.2: 0.25 h

With sodium azide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;