(S)-tert-butyl (1-amino-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (1-amino-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate
CAS No.:1417654-04-6
Molecular Formula:C₂₈H₃₂I₂N₂O₅
Molecular Weight:730.381
Hs Code.:

Synonyms:(S)-tert-butyl (1-amino-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

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Chemical Property of (S)-tert-butyl (1-amino-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

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Technology Process of (S)-tert-butyl (1-amino-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

There total 6 articles about (S)-tert-butyl (1-amino-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1417654-03-5
(S)-tert-butyl (1-azido-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

: 1417654-04-6
(S)-tert-butyl (1-amino-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

Guidance literature:: With triphenylphosphine; In tetrahydrofuran; water; at 20 ℃; for 18h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1417654-04-6
(S)-tert-butyl (1-amino-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium borohydride; chloro-trimethyl-silane / tetrahydrofuran; 1,4-dioxane / 20 °C / Inert atmosphere; Cooling with ice

1.2: 3 h / pH 9 - 9.5

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide / toluene / 4.5 h / 20 °C / Cooling with ice

4.1: sodium azide / N,N-dimethyl-formamide / 24 h / 80 °C

5.1: triphenylphosphine / tetrahydrofuran; water / 18 h / 20 °C

With lithium borohydride; chloro-trimethyl-silane; sodium azide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1417654-00-2
(S)-tert-butyl (1-hydroxy-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propan-2-yl)carbamate

: 1417654-04-6
(S)-tert-butyl (1-amino-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide / toluene / 4.5 h / 20 °C / Cooling with ice

3: sodium azide / N,N-dimethyl-formamide / 24 h / 80 °C

4: triphenylphosphine / tetrahydrofuran; water / 18 h / 20 °C

With sodium azide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;