4-<(3-bromo-4-fluorophenyl)amino>-6-<(4-methoxyphenyl)methylamino>pyrido<3,4-d>pyrimidine

Base Information

Chemical Name:4-<(3-bromo-4-fluorophenyl)amino>-6-<(4-methoxyphenyl)methylamino>pyrido<3,4-d>pyrimidine
CAS No.:227311-98-0
Molecular Formula:C₂₁H₁₇BrFN₅O
Molecular Weight:454.301
Hs Code.:

Synonyms:4-<(3-bromo-4-fluorophenyl)amino>-6-<(4-methoxyphenyl)methylamino>pyrido<3,4-d>pyrimidine

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Chemical Property of 4-<(3-bromo-4-fluorophenyl)amino>-6-<(4-methoxyphenyl)methylamino>pyrido<3,4-d>pyrimidine

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Technology Process of 4-<(3-bromo-4-fluorophenyl)amino>-6-<(4-methoxyphenyl)methylamino>pyrido<3,4-d>pyrimidine

There total 1 articles about 4-<(3-bromo-4-fluorophenyl)amino>-6-<(4-methoxyphenyl)methylamino>pyrido<3,4-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 2393-23-9
4-methoxy-benzylamine

: 4-<(3-bromo-4-fluorophenyl)amino>-6-fluoropyrido<3,4-d>pyrimidine

: 227311-98-0
4-<(3-bromo-4-fluorophenyl)amino>-6-<(4-methoxyphenyl)methylamino>pyrido<3,4-d>pyrimidine

Guidance literature:: In dimethyl sulfoxide; at 100 ℃; for 16h;
DOI:10.1021/jm9806603

Reference yield: 99.0%

: 227311-98-0
4-<(3-bromo-4-fluorophenyl)amino>-6-<(4-methoxyphenyl)methylamino>pyrido<3,4-d>pyrimidine

: 227311-92-4
6-amino-4-<(3-bromo-4-fluorophenyl)amino>pyrido<3,4-d>pyrimidine

Guidance literature:: 4-<(3-bromo-4-fluorophenyl)amino>-6-<(4-methoxyphenyl)methylamino>pyrido<3,4-d>pyrimidine; With methoxybenzene; trifluoroacetic acid; at 20 ℃; for 20h;

With ammonia; at 0 - 20 ℃;

Reference yield:

: 227311-98-0
4-<(3-bromo-4-fluorophenyl)amino>-6-<(4-methoxyphenyl)methylamino>pyrido<3,4-d>pyrimidine

: N-[4-(3-bromo-4-fluoro-phenylamino)-pyrido[3,4-d]pyrimidin-6-yl]-acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / TFA / 0.5 h / Heating

2: 80 percent / EDCI*HCl, pyridine / 3 h / 0 - 5 °C

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;
DOI:10.1021/jm9806603