5-methyl-2,2-diphenyl-5-{3-[3-(prop-2-en-1-yloxy)phenoxy]azetidin-1-yl}hexanenitrile

Base Information

Chemical Name:5-methyl-2,2-diphenyl-5-{3-[3-(prop-2-en-1-yloxy)phenoxy]azetidin-1-yl}hexanenitrile
CAS No.:1355533-05-9
Molecular Formula:C₃₁H₃₄N₂O₂
Molecular Weight:466.623
Hs Code.:

Synonyms:5-methyl-2,2-diphenyl-5-{3-[3-(prop-2-en-1-yloxy)phenoxy]azetidin-1-yl}hexanenitrile

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Chemical Property of 5-methyl-2,2-diphenyl-5-{3-[3-(prop-2-en-1-yloxy)phenoxy]azetidin-1-yl}hexanenitrile

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Technology Process of 5-methyl-2,2-diphenyl-5-{3-[3-(prop-2-en-1-yloxy)phenoxy]azetidin-1-yl}hexanenitrile

There total 6 articles about 5-methyl-2,2-diphenyl-5-{3-[3-(prop-2-en-1-yloxy)phenoxy]azetidin-1-yl}hexanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 931410-10-5
methanesulfonic acid 1-(4-cyano-1,1-dimethyl-4,4-diphenylbutyl)azetidi-3-yl ester

: 1616-51-9
3-allyloxyphenol

: 1355533-05-9
5-methyl-2,2-diphenyl-5-{3-[3-(prop-2-en-1-yloxy)phenoxy]azetidin-1-yl}hexanenitrile

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 18h;
DOI:10.1021/op200233r

Reference yield:

: 521267-13-0
tert-butyl 4,4-dimethyl-1,2,3-oxathiazinane-3-carboxylate 2,2-dioxide

: 1355533-05-9
5-methyl-2,2-diphenyl-5-{3-[3-(prop-2-en-1-yloxy)phenoxy]azetidin-1-yl}hexanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

1.2: 4.25 h / Inert atmosphere

1.3: 2 h / 50 °C / Inert atmosphere

2.1: sodium carbonate / dichloromethane; water

2.2: 18 h / 70 °C

3.1: pyridine / -15 - 5 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C

With pyridine; potassium tert-butylate; sodium carbonate; caesium carbonate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/op200233r

Reference yield:

: 3-methylbutyl sulfamate

: 1355533-05-9
5-methyl-2,2-diphenyl-5-{3-[3-(prop-2-en-1-yloxy)phenoxy]azetidin-1-yl}hexanenitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: manganese(IV) oxide; dirhodium tetraacetate; [bis(acetoxy)iodo]benzene / dichloromethane / 18 h / 20 °C

2.1: dmap; triethylamine / dichloromethane / 5 - 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

3.2: 4.25 h / Inert atmosphere

3.3: 2 h / 50 °C / Inert atmosphere

4.1: sodium carbonate / dichloromethane; water

4.2: 18 h / 70 °C

5.1: pyridine / -15 - 5 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C

With pyridine; dmap; manganese(IV) oxide; dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; potassium tert-butylate; sodium carbonate; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/op200233r