5-amino-5-methyl-2,2-diphenyl-hexanenitrile hydrochloride

Base Information

Chemical Name:5-amino-5-methyl-2,2-diphenyl-hexanenitrile hydrochloride
CAS No.:1355532-89-6
Molecular Formula:C₁₉H₂₂N₂*ClH
Molecular Weight:314.858
Hs Code.:

Synonyms:5-amino-5-methyl-2,2-diphenyl-hexanenitrile hydrochloride

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Chemical Property of 5-amino-5-methyl-2,2-diphenyl-hexanenitrile hydrochloride

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Technology Process of 5-amino-5-methyl-2,2-diphenyl-hexanenitrile hydrochloride

There total 3 articles about 5-amino-5-methyl-2,2-diphenyl-hexanenitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 521267-13-0
tert-butyl 4,4-dimethyl-1,2,3-oxathiazinane-3-carboxylate 2,2-dioxide

: 86-29-3
Diphenylacetonitrile

: 1355532-89-6
5-amino-5-methyl-2,2-diphenyl-hexanenitrile hydrochloride

Guidance literature:: Diphenylacetonitrile; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

tert-butyl 4,4-dimethyl-1,2,3-oxathiazinane-3-carboxylate 2,2-dioxide; In tetrahydrofuran; at 20 ℃; for 4.25h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; at 50 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm200884j

Reference yield:

: 813440-67-4
4,4-dimethyl-[1,2,3]oxathiazinane 2,2-dioxide

: 1355532-89-6
5-amino-5-methyl-2,2-diphenyl-hexanenitrile hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 5 - 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

2.2: 4.25 h / Inert atmosphere

2.3: 2 h / 50 °C / Inert atmosphere

With dmap; potassium tert-butylate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/op200233r

Reference yield:

: 123-51-3
i-Amyl alcohol

: 1355532-89-6
5-amino-5-methyl-2,2-diphenyl-hexanenitrile hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; formic acid; isocyanate de chlorosulfonyle / dichloromethane / 2.33 h / 0 - 20 °C / Inert atmosphere

2.1: manganese(IV) oxide; dirhodium tetraacetate; [bis(acetoxy)iodo]benzene / dichloromethane / 18 h / 20 °C

3.1: dmap; triethylamine / dichloromethane / 5 - 20 °C

4.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

4.2: 4.25 h / Inert atmosphere

4.3: 2 h / 50 °C / Inert atmosphere

With pyridine; dmap; manganese(IV) oxide; dirhodium tetraacetate; formic acid; isocyanate de chlorosulfonyle; [bis(acetoxy)iodo]benzene; potassium tert-butylate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/op200233r