3-(4-chloro-phenyl)-2-phenylsulfanylmethyl-acrylic acid methyl ester

Base Information

• Chemical Name: 3-(4-chloro-phenyl)-2-phenylsulfanylmethyl-acrylic acid methyl ester
• CAS No.: 1236074-59-1
• Molecular Formula: C₁₇H₁₅ClO₂S
• Molecular Weight: 318.824
• Mol file: 1236074-59-1.mol

Synonyms:3-(4-chloro-phenyl)-2-phenylsulfanylmethyl-acrylic acid methyl ester

Chemical Property of 3-(4-chloro-phenyl)-2-phenylsulfanylmethyl-acrylic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-(4-chloro-phenyl)-2-phenylsulfanylmethyl-acrylic acid methyl ester

There total 4 articles about 3-(4-chloro-phenyl)-2-phenylsulfanylmethyl-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,1'-sulfinylbisbenzene (945-51-7) + methyl (2Z)-2-(bromomethyl)-3-(4-chlorophenyl)prop-2-enoate (139413-75-5) → 3-(4-chloro-phenyl)-2-phenylsulfanylmethyl-acrylic acid methyl ester (1236074-59-1)

Guidance literature:

With bis(1-methyl-1-phenylethyl)peroxide; diphenyldisulfane; at 80 ℃; for 12h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2017.05.088

Reference yield: 76.0%

diphenyldisulfane (882-33-7) + methyl-(2Z)-3-(4-chlorophenyl)-2-(iodomethyl)-propenoate → 3-(4-chloro-phenyl)-2-phenylsulfanylmethyl-acrylic acid methyl ester (1236074-59-1)

Guidance literature:

With di-tert-butyl peroxide; In acetonitrile; at 80 ℃; for 48h; stereoselective reaction; Inert atmosphere;

DOI:10.1039/c7ra04817c

Reference yield: 73.0%

methyl 3-acetoxy-3-(4-chlorophenyl)-2-methylenepropanoate (131469-72-2) + diphenyldisulfane (882-33-7) → 3-(4-chloro-phenyl)-2-phenylsulfanylmethyl-acrylic acid methyl ester (1236074-59-1)

Guidance literature:

With palladium diacetate; triphenylphosphine; In methanol; at 20 ℃; for 14h; stereoselective reaction;

DOI:10.1080/00397910903219468

upstream raw materials:

methyl 3-acetoxy-3-(4-chlorophenyl)-2-methylenepropanoate

diphenyldisulfane

1,1'-sulfinylbisbenzene

methyl (2Z)-2-(bromomethyl)-3-(4-chlorophenyl)prop-2-enoate