Technology Process of tert-butyl (1S,2R)-2-(4-(3-(methylsulfonyl)phenylamino)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)cyclopentylcarbamate
There total 7 articles about tert-butyl (1S,2R)-2-(4-(3-(methylsulfonyl)phenylamino)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)cyclopentylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 6-((1R,2S)-2-(tert-butoxycarbonylamino)cyclopentylamino)-4-cyano-2-(3-(methylsulfonyl)phenylamino)nicotinate;
With
hydrogen; acetic acid;
20 % Pd(OH)2/C;
In
methanol;
at 20 ℃;
for 12h;
under 760.051 Torr;
With
sodium hydrogencarbonate;
In
methanol; water;
at 20 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C
3.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 100 °C / 760.05 Torr / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 60 °C
5.1: 3-chloro-benzenecarboperoxoic acid / N,N-dimethyl-formamide / 16 h / 0 - 20 °C
6.1: triethylamine / N,N-dimethyl-formamide / 12 h / 60 °C
7.1: hydrogen; acetic acid / 20 % Pd(OH)2/C / methanol / 12 h / 20 °C / 760.05 Torr
7.2: 6 h / 20 °C
With
n-butyllithium; hydrogen; potassium carbonate; acetic acid; triethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
tetrakis(triphenylphosphine) palladium(0); 20 % Pd(OH)2/C;
In
tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 60 °C
2.1: 3-chloro-benzenecarboperoxoic acid / N,N-dimethyl-formamide / 16 h / 0 - 20 °C
3.1: triethylamine / N,N-dimethyl-formamide / 12 h / 60 °C
4.1: hydrogen; acetic acid / 20 % Pd(OH)2/C / methanol / 12 h / 20 °C / 760.05 Torr
4.2: 6 h / 20 °C
With
hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
20 % Pd(OH)2/C;
In
methanol; N,N-dimethyl-formamide; acetonitrile;
